1.14.11.49: uridine-5'-phosphate dioxygenase

This is an abbreviated version!
For detailed information about uridine-5'-phosphate dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.49

Reaction

UMP
+
2-oxoglutarate
+
O2
=
5'-dehydrouridine
+
succinate
+
CO2
+
phosphate

Synonyms

alpha-ketoglutarate:UMP dioxygenase, alpha-KG:UMP dioxygenase, LIPL, UMP:alpha-ketoglutarate dioxygenase, uridine-5-monophosphate alpha-ketoglutarate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.49 uridine-5'-phosphate dioxygenase

Systematic Name

Systematic Name on EC 1.14.11.49 - uridine-5'-phosphate dioxygenase

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SYSTEMATIC NAME
IUBMB Comments
UMP,2-oxoglutarate:oxygen oxidoreductase
The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.