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1.14.11.48: xanthine dioxygenase

This is an abbreviated version!
For detailed information about xanthine dioxygenase, go to the full flat file.

Reaction

xanthine
+
2-oxoglutarate
 +
O2
=
Urate
 +
succinate
 +
CO2

Synonyms

alpha-ketoglutarate-dependent xanthine hydroxylase, AO090001000152, TauD domain-containing protein, XanA, xanthine/alpha-ketoglutarate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.48 xanthine dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.48 - xanthine dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6,8-dihydroxypurine
Co2+
-
0.04 mM, about 65% inhibition
Cu2+
-
0.04 mM, complete inhibition
Fe2+
-
depending on the experimental conditions, Fe2+ concentrations of above 0.025 mM can lead to enzyme inhibition of the recombinant enzyme isolated from Escherichia coli, whereas the enzyme from Aspergillus nidulans is not inhibited at Fe2+ concentrations up to 0.080 mM
Mn2+
-
0.04 mM, about 80% inhibition
N-oxalylglycine
-
competes with 2-oxoglutarate
Zn2+
-
0.04 mM, complete inhibition