1.14.11.48: xanthine dioxygenase
This is an abbreviated version!
For detailed information about xanthine dioxygenase, go to the full flat file.
Reaction
Synonyms
alpha-ketoglutarate-dependent xanthine hydroxylase, AO090001000152, TauD domain-containing protein, XanA, xanthine/alpha-ketoglutarate dioxygenase
ECTree
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Engineering
Engineering on EC 1.14.11.48 - xanthine dioxygenase
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C357A
enhanced activity towards 9-methylxanthine as compared to wild-type enzyme. Mutant enzyme is resistant rto thiol-specific reagents that inactivated wild-type enzyme. Elevated ferroxidase activity in the absence of substrates
D138A
enhanced activity towards 9-methylxanthine as compared to wild-type enzyme. Significant decrease in Ki(app) for 6,8-dihydroxypurine
E137A
enhanced activity towards 9-methylxanthine as compared to wild-type enzyme. Significant decrease in Ki(app) for 6,8-dihydroxypurine
H340A
mutant enzyme exhibits 0.17% of the wild-type enzyme activity
K122A
2fold increase in the Kd of 2-oxoglutarate compared to wild-type enzyme
N358A
23fold decrease in kcat/Km compared to wild-type enzyme. Significant decrease in Ki(app) for 6,8-dihydroxypurine
Q356A
significant decrease in Ki(app) for 6,8-dihydroxypurine. Elevated ferroxidase activity in the absence of substrates