1.14.11.43: (S)-dichlorprop dioxygenase (2-oxoglutarate)

This is an abbreviated version!
For detailed information about (S)-dichlorprop dioxygenase (2-oxoglutarate), go to the full flat file.

Reaction

(S)-(2,4-dichlorophenoxy)propanoate
+
2-oxoglutarate
+
O2
=
2,4-Dichlorophenol
+
pyruvate
+
succinate
+
CO2

Synonyms

(S)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, 2-oxoglutarate-dependent (S)-dichlorprop dioxygenase, alpha-ketoglutarate-dependent (S)-dichlorprop dioxygenase, SdpA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.43 (S)-dichlorprop dioxygenase (2-oxoglutarate)

Substrates Products

Substrates Products on EC 1.14.11.43 - (S)-dichlorprop dioxygenase (2-oxoglutarate)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2
2,4-dichlorophenol + pyruvate + succinate + CO2
show the reaction diagram
i.e. (S)-dichlorprop, the enzyme is involved in the degradation of phenoxyalkanoic acid herbicides in Sphingomonas herbicidovorans MH. SdpA activity is completely absent in the absence of 2-oxoglutarate
-
-
?
(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2
2-methyl-4-chlorophenol + pyruvate + succinate + CO2
show the reaction diagram
i.e. (S)-mecoprop, the enzyme is involved in the degradation of phenoxyalkanoic acid herbicides in Sphingomonas herbicidovorans MH. SdpA activity is completely absent in the absence of 2-oxoglutarate
-
-
?
(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2
2,4-dichlorophenol + pyruvate + succinate + CO2
show the reaction diagram
(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2
4-chloro-2-methylphenol + pyruvate + succinate + CO2
show the reaction diagram
additional information
?
-
-
construction of homology models of SdpA and RdpA from Sphingomonas herbicidovorans MH and the use of docking to identify residues likely to be involved in herbicide binding
-
-
-