1.14.11.42: tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase

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For detailed information about tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase, go to the full flat file.

Reaction

Synonyms

tRNA wybutosine-synthesizing protein 5, tRNA yW-synthesizing enzyme 5, TYW5

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.42 tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase

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10	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
1	Metals/Ions
1	Natural Substrates/ Products (Substrates)
2	Organism
1	Reaction
2	Reference
1	Source Tissue
2	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name

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Substrates Products on EC 1.14.11.42 - tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2

7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2

Homo sapiens

A2RUC4

enzyme catalyzes the hydroxylation of the hypermodified nucleoside wybutoside in position 37 of tRNAPhe. Residues Y106 and L175 are required for 2-oxoglutarate binding. H160, N162, and H235 are residues in the HX(D/E)XnH motif that are required for Fe(II) binding

725408

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additional information

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Homo sapiens

A2RUC4

in the biogenesis of hydroxywybutosine, enzyme Tyw5p employs wybutosine residue 72 in tRNAPhe as a substrate by recognizing the N4-methyl group to hydroxylate the beta-carbon of the propyl group, followed by methylation and methoxycarbonylation of the side chain catalyzed by enzyme Tyw4 for completion

725408

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