1.14.11.42: tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase
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For detailed information about tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase, go to the full flat file.
Reaction
Synonyms
tRNA wybutosine-synthesizing protein 5, tRNA yW-synthesizing enzyme 5, TYW5
ECTree
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Crystallization
Crystallization on EC 1.14.11.42 - tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase
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the free and complex forms with 2-oxoglutarate and Ni(II) ion at 2.5 and 2.8 A resolution, respectively. The catalytic domain consists of a beta-jellyroll fold. The enzyme forms a homodimer through C-terminal helix bundle formation, thereby presenting a large, positively charged patch involved in tRNA binding. In a docking model of the TYW5-tRNAPhe complex, the D arm is captured by the positively charged patch, and the anticodon loop is directed into the positively charged catalytic pocket