1.14.11.4: procollagen-lysine 5-dioxygenase
This is an abbreviated version!
For detailed information about procollagen-lysine 5-dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.4
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1.14.11.4
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prolyl
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ehlers-danlos
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hydroxylysine
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jumonji
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fibrosis
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procollagens
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fragility
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domain-containing
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hydroxylases
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osteogenesis
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4-hydroxylase
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kyphoscoliosis
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imperfecta
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demethylase
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glucosyltransferase
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pyridinoline
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hypermobl
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galactosyltransferase
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contractures
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minoxidil
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hypotonia
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hydroxylysyl
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hypermobility
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bruck
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fkbp10
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hyperelasticity
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underhydroxylated
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sclera
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scoliosis
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laxity
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chick-embryo
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hyperextensibility
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2-oxoglutarate-dependent
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serpinh1
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galactosylhydroxylysyl
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ppib
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medicine
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crtap
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diagnostics
- 1.14.11.4
-
prolyl
- ehlers-danlos
- hydroxylysine
-
jumonji
- fibrosis
- procollagens
-
fragility
-
domain-containing
- hydroxylases
-
osteogenesis
-
4-hydroxylase
-
kyphoscoliosis
- imperfecta
- demethylase
-
glucosyltransferase
-
pyridinoline
-
hypermobl
-
galactosyltransferase
- contractures
- minoxidil
- hypotonia
-
hydroxylysyl
-
hypermobility
-
bruck
- fkbp10
-
hyperelasticity
-
underhydroxylated
-
sclera
- scoliosis
-
laxity
-
chick-embryo
-
hyperextensibility
-
2-oxoglutarate-dependent
-
serpinh1
-
galactosylhydroxylysyl
- ppib
- medicine
-
crtap
- diagnostics
Reaction
Synonyms
2-oxoglutarate 5-dioxygenase 2, collagen lysine hydroxylase, Jmjd6, L230, LH, LH1, LH2, LH2 (long), LH2a, LH2b, LH3, LH3/PLOD3, lysine hydroxylase, lysine, 2-oxoglutarate 5-dioxygenase, lysine-2-oxoglutarate dioxygenase, lysyl 5S-hydroxylase, lysyl hydroxylase, lysyl hydroxylase 1, lysyl hydroxylase 2, lysyl hydroxylase 2 (long), lysyl hydroxylase 2a, lysyl hydroxylase 2b, lysyl hydroxylase 3, Lysyl hydroxylase-2b, lysyl-hydroxylase 1, lysylhydroxylase 2, lysylprotocollagen dioxygenase, More, multifunctional collagen lysyl hydroxylase, oxygenase, protocollagen lysine, di-, peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase, peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase, PLOD, Plod1, PLOD2, Plod2a, Plod2b, PLOD2iso1, PLOD2iso2, PLOD3, procollagen lysyl hydroxylase 2, procollagen-lysine, procollagen-lysine 2-oxoglutarate 5-dioxygenase, procollagen-lysine 2-oxoglutarate 5-dioxygenase 2, procollagen-lysine, 2-oxoglutarate 5-dioxygenase, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, procollagen-lysine,2-oxoglutarate 5-dioxygenase, protocollagen lysine hydroxylase, protocollagen lysyl hydroxylase, telopeptide lysyl hydroxylase, TLH
ECTree
1.14.11.4 procollagen-lysine 5-dioxygenaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
p21-deficient (KC) and -replete (K) murine lung adenocarcinoma cells, increased LH2 enzyme activity
stem marrow cell, no expression of isozymes LH3 and LH2b
4 lung adenocarcinoma cell lines (KC1KC4) from lung tumors in KC mice and 2 lung adenocarcinoma cell lines (K1 and K2) from Cdkn1aWT K-rasLA1 mice. Expression levels of the third gene of interest, LH2, are 10-30 times higher in the highly metastatic KC cells and include both LH2 isoforms, full-length (LH2b) and spliced at exon 13 (LH2a)
increased LH2 enzyme activity in lung carcinoma compared to healthy lung
the expression of all PLOD family members is higher in astrocytoma than in oligoastrocytoma and oligodendroglioma
additional information
PLOD2 is mainly expressed within the tunica media of the blood vessels
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tissue expression profiles of the three isozymes are different, quantitative expression analysis, in situ localizations, overview
in the hatching larvae, LH1 is expressed in the pectoral fin bud
in the hatching larvae, LH3 is expressed in the pectoral fin bud
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different clones, osteoblastic cell line, expression of splicing vaiant 2b of isozyme LH2, but not of splicing variant 2a, expression analysis of the 3 isozymes in MC3T3-E1 cells and comparison of collagen cross-linking activities, overview
ordinary and dark, high expression of lysine hydroxylase 1
lysyl hydroxylases are expressed in white-adipose tissue of ob/ob mice, overview
lysyl hydroxylases are expressed in white-adipose tissue of ob/ob mice, wherein LH3 levels are increased compared with C57/BL controls. Expression levels of mRNAs corresponding to LH1 (Plod1) and LH3 (Plod3) are both altered in ob/ob mice, in the same direction as the changes in serum levels of adiponectin and the HMW isoforms
additional information
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developmental expression patterns of dPlod RNA and protein during embryogenesis,overview. dPlod is highly expressed in type-IV collagen-producing cells, particularly the hemocytes and fat body
additional information
the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, cartilage, spleen, liver, and placenta, not in skin, lung, aorta, and dura
additional information
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the long splicing variant of isozyme LH2 is the major ubiquitously-expressed form that is spliced into the short form, which is expressed together with the long form only in some tissues, e.g. kidney, cartilage, spleen, liver, and placenta, not in skin, lung, aorta, and dura
additional information
PLOD2 expression determination by immunhistochemic analysis
additional information
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PLOD2 expression determination by immunhistochemic analysis
additional information
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isozymes LH1 and LH2a are expressed in all tissues, isozymes LH2b and LH3 are expressed in almost all tissues, no tissue specificity
additional information
isozymes LH1 and LH2a are expressed in all tissues, isozymes LH2b and LH3 are expressed in almost all tissues, no tissue specificity
additional information
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the 3 isozymes are expressed in almost all tissues, no tissue specificity
additional information
the 3 isozymes are expressed in almost all tissues, no tissue specificity
