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1.14.11.33: DNA oxidative demethylase

This is an abbreviated version!
For detailed information about DNA oxidative demethylase, go to the full flat file.

Word Map on EC 1.14.11.33

Reaction

DNA-base-CH3
+
2-oxoglutarate
 +
O2
=
DNA-base
 +
formaldehyde
 +
succinate
 +
CO2

Synonyms

1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.33 DNA oxidative demethylase

Substrates Products

Substrates Products on EC 1.14.11.33 - DNA oxidative demethylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-ethyladenine + O2 + 2-oxoglutarate
adenine + CO2 + acetaldehyde + succinate + H+
show the reaction diagram
-
-
-
-
?
1-methyl-adenine in 5'-dAAAA-1MeA-YYAAA + 2-oxoglutarate + O2
5'-dAAAAAYYAAA + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
?
1-methyl-dAMP + 2-oxoglutarate + O2
dAMP + formaldehyde + succinate + CO2
show the reaction diagram
1-methyl-dATP + 2-oxoglutarate + O2
dATP + formaldehyde + succinate + CO2
show the reaction diagram
1-methyladenine + O2 + 2-oxoglutarate
adenine + CO2 + formaldehyde + succinate + H+
show the reaction diagram
-
-
-
-
?
2'-deoxy-1-methyl-adenosine 3'-phosphate + 2-oxoglutarate + O2
2'-deoxyadenosine 3'-phosphate + formaldehyde + succinate + CO2
show the reaction diagram
3-methylcytosine + O2 + 2-oxoglutarate
cytosine + CO2 + formaldehyde + succinate + H+
show the reaction diagram
-
-
-
-
?
d(Tpm1A) + 2-oxoglutarate + O2
d(TpA) + formaldehyde + succinate + CO2
show the reaction diagram
d(Tpm1ApT) + 2-oxoglutarate + O2
d(TpApT) + formaldehyde + succinate + CO2
show the reaction diagram
DNA-1,6-ethenoadenine + O2
DNA-adenine + glyoxal
show the reaction diagram
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
show the reaction diagram
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
?
DNA-1-(2-hydroxypropyl)-adenine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-1-ethanoadenine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-1-ethenoadenine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-1-ethyladenine + 2-oxoglutarate + O2
DNA-adenine + acetaldehyde + succinate + CO2
show the reaction diagram
DNA-1-hydroxyethyladenine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
DNA-1-methyldeoxyadenine + 2-oxoglutarate + O2
DNA-deoxyadenine + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
show the reaction diagram
DNA-2-furfurylguanosine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-2-methylguanosine + 2-oxoglutarate + O2
DNA-guanosine + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
show the reaction diagram
DNA-3-methylcytosine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
show the reaction diagram
DNA-4-methylcytosine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
show the reaction diagram
DNA-N1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
highest activity
-
-
?
DNA-tetrahydro-2-furfurylguanosine + 2-oxoglutarate + O2
?
show the reaction diagram
-
-
-
?
double-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
double-stranded DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
double-stranded DNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
methylated DNA bacteriophage M13mp18 + 2-oxoglutarate + O2
DNA bacteriophage M13mp18 + formaldehyde + succinate + CO2
show the reaction diagram
methylated double-stranded bacteriophage lambda + 2-oxoglutarate + O2
double-stranded bacteriophage lambda + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
?
methylated luciferase-mRNA + 2-oxoglutarate + O2
luciferase-mRNA + formaldehyde + succinate + CO2
show the reaction diagram
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
show the reaction diagram
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
show the reaction diagram
methylated poly(deoxythymine) + 2-oxoglutarate + O2
poly(deoxythymine) + formaldehyde + succinate + CO2
show the reaction diagram
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
show the reaction diagram
methylated single-stranded poly(deoxyadenosine) + 2-oxoglutarate + O2
single-stranded poly(deoxyadenosine) + formaldehyde + succinate + CO2
show the reaction diagram
methylated tRNA-Phe + 2-oxoglutarate + O2
tRNA-Phe + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
?
methylated tRNA-Phe + 2-oxoglutarate + O2
tRNAPhe + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
?
N1-methyl-ATP + 2-oxoglutarate + O2
ATP + formaldehyde + succinate + CO2
show the reaction diagram
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
show the reaction diagram
N1-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
-
strong substrate in ss-DNA
-
-
?
N1-methylguanine in DNA + 2-oxoglutarate + O2
guanine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
-
weak substrate in ds-DNA
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
show the reaction diagram
N3-methylcytosine in DNA + 2-oxoglutarate + O2
cytosine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
-
strong substrate in ss-DNA
-
-
?
N3-methylthymine in DNA + 2-oxoglutarate + O2
thymine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
-
weak substrate in ds-DNA
-
-
?
N6-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
show the reaction diagram
-
via 6-hydroxymethyl adenine derivative
-
-
?
poly(dm1A) + 2-oxoglutarate + O2
poly(dA) + formaldehyde + succinate + CO2
show the reaction diagram
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
show the reaction diagram
single-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
single-stranded DNA-adenine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
single-stranded DNA-cytosine + formaldehyde + succinate + CO2
show the reaction diagram
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
tRNA-1-methylguanine + 2-oxoglutarate + O2
tRNA-guanine + formaldehyde + succinate + CO2
show the reaction diagram
additional information
?
-