1.14.11.33: DNA oxidative demethylase
This is an abbreviated version!
For detailed information about DNA oxidative demethylase, go to the full flat file.
Word Map on EC 1.14.11.33
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1.14.11.33
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demethylation
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3-methylcytosine
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wobble
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1,n6-ethenoadenine
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alkbhs
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2-oxoglutarate-dependent
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dealkylation
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writer
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etheno
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epitranscriptomic
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5-methoxycarbonylmethyluridine
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n1-methyladenosine
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n6-methyladenine
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analysis
- 1.14.11.33
-
demethylation
- 3-methylcytosine
-
wobble
- 1,n6-ethenoadenine
-
alkbhs
-
2-oxoglutarate-dependent
-
dealkylation
-
writer
-
etheno
-
epitranscriptomic
-
5-methoxycarbonylmethyluridine
- n1-methyladenosine
- n6-methyladenine
- analysis
Reaction
Synonyms
1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO
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Application
Application on EC 1.14.11.33 - DNA oxidative demethylase
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analysis
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development of a fluorogenic probe design (MAQ) that is directly responsive to ALKBH3 repair activity. MAQ uses the fluorescence-quenching properties of 1-methyladenine, removal of the alkyl group results in an more than 10fold light-up signal. The probe is specific for ALKBH3 over its related homologue ALKBH2 and can be used to identify and measure the effectiveness of enzyme inhibitors. The probe functions efficiently in cells, allowing imaging and quantitation of ALKBH3 activity by microscopy and flow cytometry