1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

This is an abbreviated version!
For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.

Reaction

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia inducible factor, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, HIF1AN, hypoxia-inducible factor 1-alpha inhibitor, hypoxia-inducible factor asparagine hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

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Results	in table
5	Activating Compound
11	AA Sequence
3	Application
5	Cloned(Commentary)
2	Crystallization (Commentary)
57	Disease/ Diagnostics
1	Expression
19	General Information
13	IC50 Value
29	Inhibitors
6	kcat/KM [mM/s]
8	Ki Value [mM]
15	KM Value [mM]
9	Metals/Ions
15	Natural Substrates/ Products (Substrates)
18	Organism
29	PDB ID
4	pH Optimum
5	Protein Variants
5	Purification (Commentary)
1	Reaction
18	Reference
16	Source Tissue
37	Substrates and Products (Substrate)
1	Subunits
39	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.075

2,3-dihydroxypyridine

Homo sapiens

-

pH 7.0, 37°C

725647

0.01

2-hydroxypyridine 1-oxide

Homo sapiens

-

pH 7.0, 37°C

725647

1

3-cyano-6-methyl-2(H)-pyridinone

Homo sapiens

-

above, pH 7.0, 37°C

725647

0.03

3-hydroxy-1,2-dimethyl-4(1H)-pyridinone

Homo sapiens

-

pH 7.0, 37°C

725647

0.07

3-hydroxy-2-methyl-4-pyrone

Homo sapiens

-

above, pH 7.0, 37°C

725647

0.05

4-methylcatechol

Homo sapiens

-

pH 7.0, 37°C

725647

0.01

4-nitrocatechol

Homo sapiens

-

pH 7.0, 37°C

725647

0.12

4-tert-butylcatechol

Homo sapiens

-

pH 7.0, 37°C

725647

0.17

5-hydroxy-2-hydroxymethyl-4-pyrone

Homo sapiens

-

pH 7.0, 37°C

725647

0.05

5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid

Homo sapiens

-

pH 7.0, 37°C

725647

0.01

Co2+

Homo sapiens

-

-

698722

0.025

N-oxaloylglycine

Homo sapiens

-

-

698722

0.01

Zn2+

Homo sapiens

-

-

698722