1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

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For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.

Reaction

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia inducible factor, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, HIF1AN, hypoxia-inducible factor 1-alpha inhibitor, hypoxia-inducible factor asparagine hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

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Results

in table

5

Activating Compound

11

AA Sequence

3

Application

5

Cloned(Commentary)

2

Crystallization (Commentary)

57

Disease/ Diagnostics

5

Engineering

1

Expression

19

General Information

13

IC50 Value

29

Inhibitors

6

KCat/KM [mM/s]

8

Ki Value [mM]

15

KM Value [mM]

9

Metals/Ions

15

Natural Substrates/ Products (Substrates)

18

Organism

29

PDB ID

4

pH Optimum

5

Purification (Commentary)

1

Reaction

18

Reference

16

Source Tissue

37

Substrates and Products (Substrate)

1

Subunits

39

Synonyms

1

Systematic Name

4

Temperature Optimum [°C]

7

Turnover Number [1/s]