1.14.11.3: pyrimidine-deoxynucleoside 2'-dioxygenase
This is an abbreviated version!
For detailed information about pyrimidine-deoxynucleoside 2'-dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.3
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1.14.11.3
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thymine
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alpha-ketoglutarate
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7-hydroxylase
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ascorbate
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rhodotorula
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nidulans
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co2
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uracil
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salvage
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5-hydroxymethyluracil
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crassa
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neurospora
-
glutinis
- 1.14.11.3
- thymine
- alpha-ketoglutarate
-
7-hydroxylase
- ascorbate
-
rhodotorula
- nidulans
- co2
- uracil
-
salvage
- 5-hydroxymethyluracil
- crassa
- neurospora
- glutinis
Reaction
Synonyms
deoxyuridine 2'-dioxygenase, deoxyuridine 2'-hydroxylase, JBP1, JBP2, pyrimidine deoxyribonucleoside 2'-hydroxylase, thymidine 2'-dioxygenase, thymidine 2'-hydroxylase, thymidine 2-oxoglutarate dioxygenase, thymidine dioxygenase
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Substrates Products
Substrates Products on EC 1.14.11.3 - pyrimidine-deoxynucleoside 2'-dioxygenase
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REACTION DIAGRAM
5-hydroxymethyldeoxyuridine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
5-bromouridine + succinate + CO2
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-
-
-
?
5-bromodeoxyuridine + 2-oxoglutarate + O2
5-bromouridine + succinate + CO2
-
-
-
-
?
5-hydroxymethyluridine + succinate + CO2
-
-
-
-
?
5-hydroxymethyldeoxyuridine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
-
-
-
?
5-mehyluridine + succinate + CO2
-
-
-
-
?
6-azathymidine + 2-oxoglutarate + O2
5-mehyluridine + succinate + CO2
-
-
-
-
?
5-hydroxymethyluridine + succinate + CO2
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JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
-
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
telomeric duplex DNA substrate, JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
mass spectrometric product determination
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
-
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
telomeric duplex DNA substrate, JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
mass spectrometric product determination
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
-
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
telomeric duplex DNA substrate, JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
mass spectrometric product determination
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
-
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
telomeric duplex DNA substrate, JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
mass spectrometric product determination
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
-
-
?
thymidine + 2-oxoglutarate + O2
5-hydroxymethyluridine + succinate + CO2
-
telomeric duplex DNA substrate, JBP1 hydroxylates thymine specifically in the context of dsDNA in a Fe2+-, 2-oxoglutarate-, and O2-dependent manner
mass spectrometric product determination
-
?
5-methyluridine + succinate + CO2
-
-
-
-
?
thymidine + 2-oxoglutarate + O2
5-methyluridine + succinate + CO2
-
conversion to the ribonucleotide prior to its utilization for DNA synthesis
-
?
thymidine + 2-oxoglutarate + O2
5-methyluridine + succinate + CO2
-
conversion to the ribonucleotide prior to its utilization for DNA synthesis
-
?
5-methyluridine 5'-phosphate + succinate + CO2
-
-
-
-
?
thymidylate + 2-oxoglutarate + O2
5-methyluridine 5'-phosphate + succinate + CO2
-
-
-
-
?
?
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-
thymine in the context of single stranded DNA substrate, rather than duplex DNA, is not hydroxylated
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-
?
additional information
?
-
-
thymine in the context of single stranded DNA substrate, rather than duplex DNA, is not hydroxylated
-
-
?
additional information
?
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-
only pyrimidine deoxyribonucleosides with oxygen at carbon 2 and 4 are active
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-
?
additional information
?
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only pyrimidine deoxyribonucleosides with oxygen at carbon 2 and 4 are active
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-
?
additional information
?
-
-
thymine in the context of single stranded DNA substrate, rather than duplex DNA, is not hydroxylated
-
-
?
additional information
?
-
-
thymine in the context of single stranded DNA substrate, rather than duplex DNA, is not hydroxylated
-
-
?
additional information
?
-
-
thymine in the context of single stranded DNA substrate, rather than duplex DNA, is not hydroxylated
-
-
?