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1.14.11.29: hypoxia-inducible factor-proline dioxygenase

This is an abbreviated version!
For detailed information about hypoxia-inducible factor-proline dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.29

Reaction

hypoxia-inducible factor-L-proline
+
2-oxoglutarate
 +
O2
=
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline
 +
succinate
 +
CO2

Synonyms

Egl nine homolog 1, EGLN, EGLN1, Egln2, EGLN3, factor inhibiting HIF, FIH, HIF hydroxylase, HIF prolyl, HIF prolyl 4-hydroxylase, HIF prolyl hydroxylase, HIF-1alpha PHD3, HIF-1alpha prolyl hydroxylase 3, HIF-alpha prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HIF-PH, Hif-prolyl hydroxylase, HIF-prolyl hydroxylase domain 2, HIF-prolyl hydroxylase-2, HPH-1, HPH-2, HPH-3, hydroxylase domain enzyme, hypoxia-inducible factor prolyl hydroxylase 2, hypoxia-inducible factor prolyl hydroxylase domain 2, P4H-TM, PHD, PHD1, PHD2, PHD3, proline hydroxylase domain 2, prolyl 4-hydroxylase, prolyl hydroxylase, prolyl hydroxylase domain, prolyl hydroxylase domain protein, prolyl hydroxylase domain protein 2, prolyl hydroxylase-2, prolyl-4-hydroxylase 2, prolyl-4-hydroxylase domain 2, transmembrane prolyl 4-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.29 hypoxia-inducible factor-proline dioxygenase

Expression

Expression on EC 1.14.11.29 - hypoxia-inducible factor-proline dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after hypoxia treatment the enzyme expression is significantly increased in all analyzed tissues
at 8 weeks of age the Hif-p4h isoforms 1, 2 and 3 are expressed in the jejunum epithelium at similar levels of 27, 35 and 29 copies/fg RNA. At 3 and 16 weeks of age, Hif-p4h-3 seems to have a slightly higher expression level than the other two isoforms. The caecum epithelium, Hif-p4h-2 has the highest abundance (109 copies/fg RNA input at 8 weeks of age) of the Hif-p4h isoforms, which is significantly higher when compared to Hif-p4h-3 (39 copies/fg RNA input). In the colon epithelium Hif-p4h-2 mRNA has the highest abundance (44 copies/fg RNA input) among the Hif-p4h isoforms, which is significantly higher than that of Hif-p4h-1 (18 copies/fg RNA input) and Fih1 (15 copies/fg RNA input), while the difference between the Hif-p4h-2 and Hif-p4h-3 (30 copies/fg RNA input) mRNA levels do not reach statistical significance
isozyme PHD3 is induced in cells in hypoxia in a HIF-dependent manner and plays a role in a negative-feedback loop
the expression of prolyl 4-hydroxylase domain protein 3 (PHD3) increases under hypoxia. Fibrosis improves when PHD3 is overexpressed