1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

1.14.11.27

demethylases

chromatin

demethylation

h3k9me3

trimethylation

jumonji

tumorigenesis

methyltransferases

lysine-specific

heterochromatin

tri-methylated

tudor

chromatin-modifying

jmjd1a

jmjc-domain-containing

setdb1

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine36

+ 2 2-oxoglutarate + 2 O2 =

+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl�specific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

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Results	in table
4	Activating Compound
1348	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
1894	Disease/ Diagnostics
2	Expression
45	General Information
8	Localization
4	Metals/Ions
2	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
94	Organism
113	PDB ID
1	Posttranslational Modification
24	Protein Variants
4	Purification (Commentary)
3	Reaction
30	Reference
28	Source Tissue
52	Substrates and Products (Substrate)
4	Subunits
77	Synonyms
1	Systematic Name

Activating Compound

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Activating Compound on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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ascorbate

2 entries

fisetin

Homo sapiens

O75164

fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin

764436

HP1a

Drosophila melanogaster

H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association

701212