1.14.11.18: phytanoyl-CoA dioxygenase

This is an abbreviated version!
For detailed information about phytanoyl-CoA dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.18

Reaction

phytanoyl-CoA
+
2-oxoglutarate
+
O2
=
2-hydroxyphytanoyl-CoA
+
succinate
+
CO2

Synonyms

PAHX, PhyH, Phytanic acid oxidase, phytanoyl-CoA 2-hydroxylase, Phytanoyl-CoA alpha-hydroxylase, phytanoyl-CoA hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.18 phytanoyl-CoA dioxygenase

Specific Activity

Specific Activity on EC 1.14.11.18 - phytanoyl-CoA dioxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000001
-
in kidney cell line COS-1, activity can be induced 4fold by phytanic acid
0.0000018
-
in embryonic carcinoma cell line P19-EC, activity can be induced 4fold by phytanic acid
0.000002
-
in kidney cell line 293, activity can be induced 4fold by phytanic acid
0.0000022
-
in fibroblast homogenate
0.0000031
-
in hepatoma cell line HepG2, no induction by phytanic acid
0.000024
-
in hepatoma cell line FaO, activity can be induced 2.5fold by phytanic acid
0.000041
-
in liver homogenate
0.0001
-
in purified peroxisomes
0.00026
-
in purified liver peroxisomes