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1.14.11.18: phytanoyl-CoA dioxygenase

This is an abbreviated version!
For detailed information about phytanoyl-CoA dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.18

Reaction

phytanoyl-CoA
+
2-oxoglutarate
 +
O2
=
2-hydroxyphytanoyl-CoA
 +
succinate
 +
CO2

Synonyms

PAHX, PhyH, PHYHD1, Phytanic acid oxidase, phytanoyl-CoA 2-hydroxylase, Phytanoyl-CoA alpha-hydroxylase, phytanoyl-CoA dioxygenase domain containing protein 1, phytanoyl-CoA hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.18 phytanoyl-CoA dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.18 - phytanoyl-CoA dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-methylhexadecanoyl-CoA
-
56% of control activity
ATP
at 0.1 mM Fe2+ 4 mM ATP inhibits enzyme activity. At increased Fe2+ concentrations ATP stimulates with a maximum at 64 mM ATP for 1.0 mM Fe2+
GTP
at 0.1 mM Fe2+ 4 mM ATP inhibits enzyme activity. At increased Fe2+ concentrations ATP stimulates with a maximum at 64 mM ATP for 1.0 mM Fe2+
hexadecanoyl-CoA
-
74% of control activity
propyl gallate
-
no activity with 1 mM, interacts with iron binding
additional information
-
not inhibited by bifonazole, clotrimazole, miconazole, ketoconazole
-