1.14.11.16: peptide-aspartate beta-dioxygenase

This is an abbreviated version!
For detailed information about peptide-aspartate beta-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.16

1.14.11.16

prolyl

hydroxylases

oxygen-dependent

ankyrin

hif-alpha

oxygen-sensing

junctin

humbug

fih-dependent

fih-mediated

alpha-ketoglutarate-dependent

junctate

medicine

analysis

Reaction

peptide-L-aspartate

+

2-oxoglutarate

+

O2

=

peptide-3-hydroxy-L-aspartate

+

succinate

+

CO2

Synonyms

AAH, asparaginyl hydroxylase factor inhibiting HIF-1, aspartate beta-hydroxylase, aspartate-beta-hydroxylase, aspartate/asparagine-beta-hydroxylase, aspartyl (asparaginyl) beta-hydroxylase, aspartyl (asparaginyl)-beta-hydroxylase, aspartyl beta-hydroxylase, aspartyl-(asparaginyl) beta-hydroxylase, aspartyl-(asparaginyl)-b-hydroxylase, aspartyl-(asparaginyl)-beta-hydroxylase, aspartyl-(asparagyl)-beta-hydroxylase, aspartyl-asparaginyl-beta-hydroxylase, aspartyl/asparaginyl beta-hydroxylase, aspartylpeptide beta-dioxygenase, ASPH, EGF beta-hydroxylase, EGFH, factor inhibiting HIF, factor inhibiting hypoxia-inducible factor, factor inhibiting hypoxia-inducible transcription factor (HIF), factor-inhibiting hypoxia-inducible factor, FIH, HAAH, HIF asparaginyl hydroxylase, human aspartyl (asparaginyl) beta-hydroxylase, hypoxia-inducible factor asparaginyl hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.16 peptide-aspartate beta-dioxygenase

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Results	in table
2	Activating Compound
235	AA Sequence
7	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
162	Disease/ Diagnostics
13	Expression
24	General Information
77	IC50 Value
87	Inhibitors
4	kcat/KM [mM/s]
25	KM Value [mM]
12	Localization
14	Metals/Ions
10	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
49	Organism
45	PDB ID
2	pH Optimum
1	pH Range
1	Posttranslational Modification
18	Protein Variants
14	Purification (Commentary)
1	Reaction
7	Reaction Type
49	Reference
61	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
48	Substrates and Products (Substrate)
3	Subunits
65	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
8	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.16 - peptide-aspartate beta-dioxygenase

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0.0193

(1S,2S,4R)-3-oxalobicyclo[2.2.1]hept-5-ene-2-carboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00025

(R)-gossypol

Homo sapiens

pH 7.5, 20°C

-

0.0033

1-oxalocyclopropane-1-carboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0003

2,2-dimethyl-4-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00051

2-(2-methylpropyl)-4-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0007

2-(3,3-dimethylbutyl)-4-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00043

2-benzyl-4-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00061

2-ethyl-4-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00052

2-oxalocyclopropane-1-carboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0068

2-oxo-3-(3-phenylpropyl)pentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0057

2-oxo-3-propylpentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0063

2-oxo-3-[[4-(trifluoromethoxy)phenyl]methyl]pentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00025

2-oxo-4-(3-phenylpropyl)pentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00047

2-oxo-4-propylpentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00017

2-[(naphthalen-2-yl)methyl]-4-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0109

3-((3-phenylpropyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00186

3-((4-(trifluoromethyl)benzyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00367

3-((4-chlorophenethyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00058

3-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0108

3-((4-phenylbutyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0131

3-((cyclohexylmethyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00467

3-(2-aminoanilino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0104

3-(2-carboxyanilino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0221

3-(2-fluoroanilino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0138

3-(2-methoxyanilino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0129

3-(2-methylanilino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0161

3-(2-nitroanilino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0482

3-(3,3-dimethylbutyl)-2-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.00395

3-(benzylamino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00766

3-(phenethylamino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0388

3-anilinopyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0016

3-benzyl-2-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.012

3-ethyl-2-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0047

3-[(3,5-dimethylphenyl)methyl]-2-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0026

3-[(4-fluorophenyl)methyl]-2-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0036

3-[(4-methoxyphenyl)methyl]-2-oxopentanedioic acid

Homo sapiens

pH 7.5, 20°C

-

0.0161

3-[2-(methylsulfanyl)anilino]pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0129

5-oxalothiophene-2-carboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00307

AS-8351

Homo sapiens

pH 7.5, 20°C

-

0.00749

belinostat

Homo sapiens

pH 7.5, 20°C

0.00147

bleomycin A2

Homo sapiens

pH 7.5, 20°C

0.00439

ciclopirox olamine

Homo sapiens

pH 7.5, 20°C

0.00039

Co2+

Homo sapiens

pH 7.5, 20°C

0.0111

daprodustat

Homo sapiens

pH 7.5, 20°C

-

0.00208

deferasirox

Homo sapiens

pH 7.5, 20°C

-

0.00489

deferiprone

Homo sapiens

pH 7.5, 20°C

0.00316

deferoxamine mesylate

Homo sapiens

pH 7.5, 20°C

0.0163

desidustat

Homo sapiens

pH 7.5, 20°C

-

0.00012

ebselen

Homo sapiens

pH 7.5, 20°C

0.129

GSK-J1

Homo sapiens

pH 7.5, 20°C

0.00007

IOX1

Homo sapiens

pH 7.5, 20°C

0.00424

JIB-04

Homo sapiens

pH 7.5, 20°C

0.00506

L-mimosine

Homo sapiens

pH 7.5, 20°C

0.00943

midostaurin

Homo sapiens

pH 7.5, 20°C

0.0095

mithramycin A

Homo sapiens

pH 7.5, 20°C

0.00465

ML324

Homo sapiens

pH 7.5, 20°C

-

0.00506

Mn2+

Homo sapiens

pH 7.5, 20°C

0.01342

molidustat

Homo sapiens

pH 7.5, 20°C

-

0.00103

navitoclax

Homo sapiens

pH 7.5, 20°C

-

0.00017

Ni2+

Homo sapiens

pH 7.5, 20°C

0.01547

NOFD

Homo sapiens

pH 7.5, 20°C

-

0.0129

obatoclax

Homo sapiens

pH 7.5, 20°C

-

0.00014

PBIT

Homo sapiens

pH 7.5, 20°C

-

0.0132

plicamycin

Homo sapiens

pH 7.5, 20°C

-

0.00051

pyridine-2,3-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

0.00002 - 0.00003

pyridine-2,4-dicarboxylic acid

show

0.00548

pyridine-2,6-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

0.00028

rac-3-((1-phenylethyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.00122

rac-3-((1-phenylpropyl)amino)pyridine-2,4-dicarboxylic acid

Homo sapiens

pH 7.5, 20°C

-

0.0194

roxadustat

Homo sapiens

pH 7.5, 20°C

-

0.00666

TC-E 5002

Homo sapiens

pH 7.5, 20°C

-

0.00412

tubacin

Homo sapiens

pH 7.5, 20°C

0.00439

vadadustat

Homo sapiens

pH 7.5, 20°C

-

0.00338

vemurafenib

Homo sapiens

pH 7.5, 20°C

-

0.0014

venetoclax

Homo sapiens

pH 7.5, 20°C

-

0.00005

Zn2+

Homo sapiens

pH 7.5, 20°C

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Release 2023.1 (January 2023)