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1.14.11.11: hyoscyamine (6S)-dioxygenase

This is an abbreviated version!
For detailed information about hyoscyamine (6S)-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.11

Reaction

L-hyoscyamine
+
2-oxoglutarate
 +
O2
=
(6S)-hydroxyhyoscyamine
 +
succinate
 +
CO2

Synonyms

6H6, AaH6H, AtH6H, Dih6h, H6H, HnH6H, hyoscyamine 6-hydroxylase, hyoscyamine 6beta-hydroxylase, hyoscyamine-6beta-hydroxylase, oxygenase, hyoscyamine 6beta-di-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.11 hyoscyamine (6S)-dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.11 - hyoscyamine (6S)-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R,4S,5S,7s)-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
-
slight inhibition by the substrate analogue
1,10-phenanthroline
-
0.1 mM, 35% inhibition
1-methylpiperidin-4-yl 2-phenylacetate
-
-
2,2'-dipyridyl
-
0.1 mM, 15% inhibition
3,4-dihydroxybenzoate
-
-
3,4-dihydroxycinnamate
-
-
3,4-dihydroxymandelate
-
-
3,4-Dihydroxyphenylacetate
-
-
3,4-Dihydroxyphenylpropionate
-
-
3-oxoglutaric acid
-
-
5,7-dehydrohyoscyamine
-
-
6,7-Dehydrohyoscyamine
-
-
8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-(4-(dimethylamino)phenyl)acetate
-
-
8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-phenylpropanoate
-
-
8-methyl-8-azabicyclo[3.2.1]octan-3-yl benzoate
-
-
8-oxabicyclo[3.2.1]octan-3-yl 2-phenylacetate
-
-
Apoatropine
-
-
Bathocuproine
-
0.1 mM, 27% inhibition
Cd2+
-
0.4 mM, complete inhibition
Co2+
-
0.4 mM, complete inhibition
diethyldithiocarbamate
-
0.1 mM, 37% inhibition
fumarate
-
-
Hg2+
-
0.4 mM, 96% inhibition
L-Homatropine
-
-
Mg2+
5 mM, 14% inhibition
nitroblue tetrazolium
-
-
Noratropine-N-acetic acid
-
-
Phenylacetyltropine
-
-
pyridine 2,3-dicarboxylate
-
competitive with respect to 2-oxoglutarate
Pyridine 2,4-dicarboxylate
-
competitive with respect to 2-oxoglutarate
Pyridine 3,4-dicarboxylate
-
-
Tiron
-
0.1 mM, 44% inhibition
additional information
-
synthesis and inhibitory potencies of substrate analogues, overview. No inhibition by substrate analogues 1-methylpiperidin-4-yl 2-phenylacetate, 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-phenylpropanoate, and 8-oxabicyclo[3.2.1]octan-3-yl 2-phenylacetate
-