1.13.99.3: tryptophan 2'-dioxygenase

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For detailed information about tryptophan 2'-dioxygenase, go to the full flat file.

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Synonyms

indole-3-alkane alpha-hydroxylase, indolyl-3-alkane alpha-hydroxylase, oxidase, tryptophan side-chain alpha,beta-, oxidase, tryptophan side-chain alpha,beta-, II, tryptophan side chain oxidase, tryptophan side chain oxidase II, tryptophan side chain oxidase type I, tryptophan side-chain alpha,beta-oxidase, tryptophan side-chain oxidase, TSO, TSO I, TSO II, TSOII

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.99 Miscellaneous

                1.13.99.3 tryptophan 2'-dioxygenase

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2	Activating Compound
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2	CAS Registry Number
10	Cofactor
2	Crystallization (Commentary)
5	Disease/ Diagnostics
1	General Information
15	Inhibitors
17	KM Value [mM]
4	Metals/Ions
14	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
5	Pathway
4	pH Optimum
6	pH Stability
1	pI Value
2	Protein Variants
4	Purification (Commentary)
4	Reaction
3	Reaction Type
16	Reference
4	Specific Activity [micromol/min/mg]
3	Storage Stability
74	Substrates and Products (Substrate)
6	Subunits
14	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.13.99.3 - tryptophan 2'-dioxygenase

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SYSTEMATIC NAME

IUBMB Comments

L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)

A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.