1.13.99.3: tryptophan 2'-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2'-dioxygenase, go to the full flat file.

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Synonyms

indole-3-alkane alpha-hydroxylase, indolyl-3-alkane alpha-hydroxylase, oxidase, tryptophan side-chain alpha,beta-, oxidase, tryptophan side-chain alpha,beta-, II, tryptophan side chain oxidase, tryptophan side chain oxidase II, tryptophan side chain oxidase type I, tryptophan side-chain alpha,beta-oxidase, tryptophan side-chain oxidase, TSO, TSO I, TSO II, TSOII

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.99 Miscellaneous

                1.13.99.3 tryptophan 2'-dioxygenase

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Results	in table
2	Activating Compound
1	Application
2	CAS Registry Number
10	Cofactor
2	Crystallization (Commentary)
5	Disease/ Diagnostics
1	General Information
15	Inhibitors
17	KM Value [mM]
4	Metals/Ions
14	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
5	Pathway
4	pH Optimum
6	pH Stability
1	pI Value
2	Protein Variants
4	Purification (Commentary)
4	Reaction
3	Reaction Type
16	Reference
4	Specific Activity [micromol/min/mg]
3	Storage Stability
74	Substrates and Products (Substrate)
6	Subunits
14	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]

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Reference on EC 1.13.99.3 - tryptophan 2'-dioxygenase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

439304

Takai, K.; Hayaishi, O.

Purification and properties of tryptophan side chain oxidase types I and II from Pseudomonas

Methods Enzymol.

142

195-217

1987

Pseudomonas fluorescens

3037258

brenda

439305

Noda, Y.; Takai, K.; Tokuyama, T.; Narumiya, S.; Ushiro, H.; Hayaishi, O.

Enzymatic oxidation of acetyltryptophanamide- and tryptophan-containing peptides. Formation of dehydrotryptophan

J. Biol. Chem.

252

4413-4415

1977

Pseudomonas sp.

863932

brenda

439306

Takai, K.; Sasai, Y.; Morimoto, H.; Yamazaki, H.; Yoshii, H.; Inoue, S.

Enzymatic dehydrogenation of tryptophan residues of human globins by tryptophan side chain oxidase II

J. Biol. Chem.

259

4452-4457

1984

Pseudomonas sp.

6707013

brenda

439307

Takai, K.; Ushiro, H.; Noda, Y.; Narumiya, S.; Tokuyama, T.; Hayaishi, O.

cristalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives

J. Biol. Chem.

252

2638-2656

1977

Pseudomonas sp.

-

brenda

439308

Narumiya, S.; Takai, K.; Tokuyama, T.; Noda, Y.; Ushiro, H.; Hayaishi, O.

A new metabolic pathway of tryptophan initiated by tryptophan side chain oxidase

J. Biol. Chem.

254

7007-7015

1979

Pseudomonas fluorescens

110802

brenda

439309

Roberts, J.; Rosenfeld, H.J.

Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme

J. Biol. Chem.

252

2640-2647

1977

Pseudomonas sp., Pseudomonas sp. XA

15994

brenda

439310

Zavala, F.; Takai, K.; Hayaishi, O.

Isolation and characterization of the common intermediate in dichotomous reaction catalyzed by tryptophan side chain oxidase

J. Biol. Chem.

258

344-351

1983

Pseudomonas sp.

6848506

brenda

439311

Ito, S.; Takai, K.; Tokuyama, T.; Hayaishi, O.

Enzymatic modification of tryptophan residues by tryptophan side chain oxidase I and II from Pseudomonas

J. Biol. Chem.

256

7834-7843

1981

Pseudomonas fluorescens

7263628

brenda

439312

Ushiro, H.; Takai, K.; Narumiya, S.; Ito, S.; Hayaishi, O.

Isolation and reconstitution of two electron transfer components of tryptophan side chain oxidase

J. Biol. Chem.

254

11794-11797

1979

Pseudomonas fluorescens

500674

brenda

439313

Ushiro, H.; Takai, K.; Noda, Y.; Narumiya, S.; Tokuyama, T.; Hayaishi, O.

Tryptophan side chain oxidase from Pseudomonas. Oxidation of skatole to indole-3-carboxaldehyde via indole-3-methanol

J. Biol. Chem.

253

9002-9008

1978

Pseudomonas fluorescens

721824

brenda

439314

Noda, Y.; Takai, K.; Tokuyama, T.; Narumiya, S.; Ushiro, H.; Hayaishi, O.

Tryptophan side chain oxidase from Pseudomonas. pH-Dependent formation of alpha,beta-didehydro, beta-hydroxy, and beta-keto derivatives of N-acetyltryptophanamide

J. Biol. Chem.

253

4819-4822

1978

Pseudomonas sp.

27505

brenda

439315

Ho, D.H.; Covington, W.P.; Wallerstein, R.O.; Hester, J.P.; Lin, J.R.; Brown, N.S.; Newman, R.A.; Krakoff, I.H.; Freireich, E.J.

Depletion of patients' plasma tryptophan using tryptophan side-chain oxidase columns

Cancer Invest.

11

252-257

1993

Homo sapiens

8485647

brenda

655299

Suzuki, S.; He, Y.; Oyaizu, H.

Indole-3-Acetic acid production in Pseudomonas fluorescens HP72 and its association with suppression of creeping bentgrass brown patch

Curr. Microbiol.

47

138-143

2003

Pseudomonas fluorescens, Pseudomonas fluorescens HP72

14506862

brenda

764917

Ai, Y.; Wang, B.; Xiao, S.; Luo, S.; Wang, Y.

Tryptophan side-chain oxidase enzyme suppresses hepatocellular carcinoma growth through degradation of tryptophan

Int. J. Mol. Sci.

22

12428

2021

Pseudomonas sp. ATCC 29574

34830310

brenda

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