1.13.12.9: phenylalanine 2-monooxygenase

This is an abbreviated version!
For detailed information about phenylalanine 2-monooxygenase, go to the full flat file.

Reaction

Synonyms

L-Phe oxidase, L-phenylalanine oxidase, L-phenylalanine oxidase (deaminating and decarboxylating), oxidase, phenylalanine (deaminating, decarboxylating), PAOpt, proPAO

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

                1.13.12.9 phenylalanine 2-monooxygenase

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Results	in table
2	Activating Compound
13	AA Sequence
2	Application
3	CAS Registry Number
3	Cloned(Commentary)
5	Cofactor
3	Crystallization (Commentary)
14	Inhibitors
6	Ki Value [mM]
20	KM Value [mM]
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
78	Organism
2	Pathway
12	PDB ID
3	pH Optimum
1	pH Range
17	Protein Variants
4	Purification (Commentary)
3	Reaction
5	Reaction Type
20	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
61	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
2	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.13.12.9 - phenylalanine 2-monooxygenase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

complexed with L-Phe and L-Met, vapor diffusion method, using 0.1 M HEPES (pH 7.5) and 1.0 M ammonium sulfate

Pseudomonas sp.

Q5W9R9

727793

crystal structure of PAOpt individually complexed with L-Phe and L-Met is constructed at constructed at 1.0-1.25 A resolution. The benzene ring of L-Phe is packed in six hydrophobic amino acid side chains versus the two hydrophobic side chains of L-amino acid oxidase. The distance between the substrate Calpha atom and water is shorter in the PAOpt-L-Met complex than in the PAOpt-L-Phe complex

Pseudomonas sp.

Q5W9R9

727793

crystals of noncatalytic proenzyme, activated enzyme, and enzyme o-amino benzoate complex, purified protein in 10 mM Tris-HCl (pH 8.0), concentrated, mixed with 0.1 M HEPES (pH 7.5) and 1.7 M ammonium sulfate (for the proenzyme) or 1.0 M ammonium sulfate (for the active enzyme), 30% glycerol in buffer as cryoprotectant, the enzyme amino benzoate complex is prepared by a soaking method with the cryoprotectant

Pseudomonas sp.

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698757