1.13.12.17: dichloroarcyriaflavin A synthase
This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.
Reaction
+ 4 O2 + 4 NADH + 4 H+ = + 2 CO2 + 6 H2O + 4 NAD+
Synonyms
CYP245A1, cytochrome P450 StaP, P450 StaP, StaP
ECTree
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Systematic Name
Systematic Name on EC 1.13.12.17 - dichloroarcyriaflavin A synthase
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dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming)
The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold [1]. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A [2]. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine [3].