1.13.12.15: 3,4-dihydroxyphenylalanine oxidative deaminase
This is an abbreviated version!
For detailed information about 3,4-dihydroxyphenylalanine oxidative deaminase, go to the full flat file.
Word Map on EC 1.13.12.15
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1.13.12.15
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deamination
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serotonin
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l-aromatic
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amines
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ammonia
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half-transamination
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5'-phosphate
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5-hydroxytryptamine
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transamination
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coenzyme-binding
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co2
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aerobiosis
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decarboxylation-dependent
- 1.13.12.15
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deamination
- serotonin
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l-aromatic
- amines
- ammonia
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half-transamination
- 5'-phosphate
- 5-hydroxytryptamine
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transamination
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coenzyme-binding
- co2
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aerobiosis
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decarboxylation-dependent
Reaction
2 L-dopa + = 2 3,4-dihydroxyphenylpyruvate + 2 NH3
Synonyms
3,4-dihydroxy-L-phenylalanine: oxidative deaminase, 3,4-dihydroxyphenylalanine oxidative deaminase, DDC, DOPA decarboxylase, DOPA oxidative deaminase, DOPAODA, oxidative deaminase
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Turnover Number
Turnover Number on EC 1.13.12.15 - 3,4-dihydroxyphenylalanine oxidative deaminase
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4.5
L-Dopa
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Y332F DDC mutant, reaction in 50 mM Hepes, pH 7.5, at 25°C causes the production of ammonia and 3,4-dihydroxyphenylacetaldehyde along with the consumption of molecular oxygen in a 1:2 molar ratio
additional information
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mutant T246A presents a decarboxylase activity, the kcat value is decreased by 29fold with respect to wild-type, an oxidative deamination reaction of aromatic amines does not occur
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additional information
additional information
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T246A mutant catalyzes the oxidative deamination of D-tryptophan methyl ester with a kcat value approximately 5% with respect to the measured value for wild-type
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