1.13.12.15: 3,4-dihydroxyphenylalanine oxidative deaminase

This is an abbreviated version!
For detailed information about 3,4-dihydroxyphenylalanine oxidative deaminase, go to the full flat file.

Word Map on EC 1.13.12.15

1.13.12.15

deamination

serotonin

l-aromatic

amines

ammonia

half-transamination

5'-phosphate

5-hydroxytryptamine

transamination

coenzyme-binding

co2

aerobiosis

decarboxylation-dependent

Reaction

2 L-dopa +

= 2 3,4-dihydroxyphenylpyruvate + 2 NH3

Synonyms

3,4-dihydroxy-L-phenylalanine: oxidative deaminase, 3,4-dihydroxyphenylalanine oxidative deaminase, DDC, DOPA decarboxylase, DOPA oxidative deaminase, DOPAODA, oxidative deaminase

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.12.15 3,4-dihydroxyphenylalanine oxidative deaminase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Cofactor
1	IC50 Value
3	Inhibitors
1	KM Value [mM]
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
2	Pathway
1	PDB ID
2	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
16	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.13.12.15 - 3,4-dihydroxyphenylalanine oxidative deaminase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Systematic Name Search

3,4-dihydroxy-L-phenylalanine:oxygen oxidoreductase (deaminating)

This enzyme is one of the three enzymes involved in L-dopa (3,4-dihydroxy-L-phenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought [1]), the other two being EC 4.3.1.22 (dihydroxyphenylalanine reductive deaminase) and EC 2.6.1.49 (3,4-dihydroxyphenylalanine transaminase). In addition to L-dopa, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. The enzyme is inhibited by NADH and 2-oxoglutarate.