1.13.12.15: 3,4-dihydroxyphenylalanine oxidative deaminase

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For detailed information about 3,4-dihydroxyphenylalanine oxidative deaminase, go to the full flat file.

Word Map on EC 1.13.12.15

1.13.12.15

deamination

serotonin

l-aromatic

amines

ammonia

half-transamination

5'-phosphate

5-hydroxytryptamine

transamination

coenzyme-binding

co2

aerobiosis

decarboxylation-dependent

Reaction

2 L-dopa +

= 2 3,4-dihydroxyphenylpyruvate + 2 NH3

Synonyms

3,4-dihydroxy-L-phenylalanine: oxidative deaminase, 3,4-dihydroxyphenylalanine oxidative deaminase, DDC, DOPA decarboxylase, DOPA oxidative deaminase, DOPAODA, oxidative deaminase

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.12.15 3,4-dihydroxyphenylalanine oxidative deaminase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Cofactor
1	IC50 Value
3	Inhibitors
1	KM Value [mM]
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
2	Pathway
1	PDB ID
2	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
16	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.13.12.15 - 3,4-dihydroxyphenylalanine oxidative deaminase

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2-oxoglutarate

Cereibacter sphaeroides

685904

3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl propionic acid

Sus scrofa

carbiDOPA, addition of 10 microM inhibitor to reaction mixtures (Y332F mutant with L-dopa) in the presence or in the absence of catalase or superoxide dismutase, immediately stops the O2 consumption.

690973

NADH

Cereibacter sphaeroides

685904