1.13.11.B6: linoleate 9/13-lipoxygenase
This is an abbreviated version!
For detailed information about linoleate 9/13-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.B6
-
1.13.11.B6
-
jasmonate
-
polyunsaturated
-
epoxy
-
cucumber
-
magnaporthe
-
apple
-
lipoxygenases
-
hydroperoxidation
-
9s-hpode
- 1.13.11.B6
- jasmonate
-
polyunsaturated
-
epoxy
- cucumber
-
magnaporthe
- apple
- lipoxygenases
-
hydroperoxidation
-
9s-hpode
Reaction
2 linoleate
+
2 O2
=
Synonyms
13/9 lipoxygenase, 13/9-LOX, 9-/13-LOXN2, 9-lipoxygenase, 9-LOX, 9/13-lipoxygenase, 9/13-LOX, Ca-LOC-1, dual positional specific LOX, linoleate 9 S-lipoxygenase, linoleate oxygen oxidoreductase, linolenate 9R-dioxygenase, lipoxygenase, LOX, lox1-St-2, LOX1-Zm1, LOX1:Md:1a, LOX1a, LOX2:Md:2a, LOX2a, manganese 9S-lipoxygenase, MoLOX1, OsLOX1, PnLOX1, S-LOX
ECTree
1.13.11.B6 linoleate 9/13-lipoxygenaseAdvanced search results
results (
results (General Information
General Information on EC 1.13.11.B6 - linoleate 9/13-lipoxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
physiological function
additional information
evolution
-
9S-LOX contains catalytic manganese, and its sequence can be aligned with 77% identity to 13R-LOX with catalytic manganese lipoxygenase of the Take-all fungus. Alterations in the Sloane determinant of 9S-LOX and 13R-MnLOX with larger and smaller hydrophobic residues interconvert the regiospecifi c oxidation of 18:2 n-6, presumably by altering the substrate position in relation to oxygen insertion
evolution
DNA and amino acid sequence determination and analysis of LOX1 and LOX2 isozymes, phylogenetic analysis, only LOX1:Md:1a exhibits a glycine residue (Gly567) responsible for dual positional specificity and (R)-LOX activity
evolution
-
9S-LOX contains catalytic manganese, and its sequence can be aligned with 77% identity to 13R-LOX with catalytic manganese lipoxygenase of the Take-all fungus. Alterations in the Sloane determinant of 9S-LOX and 13R-MnLOX with larger and smaller hydrophobic residues interconvert the regiospecifi c oxidation of 18:2 n-6, presumably by altering the substrate position in relation to oxygen insertion
-
physiological function
LOXN2 may be involved in late mechanisms of host resistance
physiological function
OsLOX1 is likely to be the main LOX involved in rice response to biotic and wounding stress. 13-LOX pathway products (such as (Z)-3-hexenyl acetate) protect plants against herbivores by inducing the production of several defence molecules and by attracting herbivore predators. products of 9-LOXs might participate in plant resistance to insect attack, as well
physiological function
the 9/13-LOX is associated with the ripening and senescence processes. Due to its dual positional specificity and its expression pattern, its contribution to the elaboration of the olive oil aroma might be considered
physiological function
lipoxygenase (LOX) is an important contributor to the formation of aroma-active C6 aldehydes in apple (Malus3domestica) fruit upon tissue disruption, role in autonomously produced aroma volatiles from intact tissue, overview. The genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio- and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits, suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples. While isozymes LOX1:Md:1c, LOX2:Md:2a, and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption isozyme, LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue. Both 9- and 13-hydroperoxides can be catabolized to aroma-active volatile aldehydes by hydroperoxide lyase. Only 13-LOX activity contributes to the apple aroma due to the formation of precursors of C6 volatile compounds. The dioxygenation of PUFAs by 9- and 13-LOX activity forms precursors for important phytooxylipins with functions in plant defense, wound signaling, senescence and fruit ripening
additional information
-
9S-MnLOX catalyzes hydrogen abstraction at C-11 and oxygenation at C-9 and C-11 in a suprafacial manner in analogy with 13R-MnLOX, EC 1.13.11.45
additional information
-
fatty acid composition of Lasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
additional information
-
fatty acid composition ofLasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
additional information
-
the bulky polar heads of glycerolipids like monolinolenoylglycerol and 2-linoleoyl-sn-glycero-3-phosphorylcholine cannot penetrate into the LOX active site. Thus, both (9S)- and (13S)-hydroperoxides can be produced when substrate is arranged within LOX active site in the methyl end first orientation
additional information
the bulky polar heads of glycerolipids like monolinolenoylglycerol and 2-linoleoyl-sn-glycero-3-phosphorylcholine cannot penetrate into the LOX active site. Thus, both (9S)- and (13S)-hydroperoxides can be produced when substrate is arranged within LOX active site in the methyl end first orientation
additional information
-
fatty acid composition of Lasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
-
additional information
-
fatty acid composition ofLasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
-
additional information
-
9S-MnLOX catalyzes hydrogen abstraction at C-11 and oxygenation at C-9 and C-11 in a suprafacial manner in analogy with 13R-MnLOX, EC 1.13.11.45
-
additional information
-
fatty acid composition of Lasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
-
additional information
-
fatty acid composition ofLasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
-
additional information
-
fatty acid composition of Lasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
-
additional information
-
fatty acid composition ofLasiodiplodia theobromae determined by GC-MS analysis after hydrolysis, overview
-
