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1.13.11.91: 3-mercaptopropionate dioxygenase

This is an abbreviated version!
For detailed information about 3-mercaptopropionate dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.91

Reaction

3-sulfanylpropanoate
+
O2
=
3-sulfinopropanoate

Synonyms

3-mercaptopropionic acid dioxygenase, 3-sulfanylpropanoate dioxygenase, 3MDO, 3MP dioxygenase, CdoA, H16_B1863, MDO, NP_251292, PA2602

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.91 3-mercaptopropionate dioxygenase

Engineering

Engineering on EC 1.13.11.91 - 3-mercaptopropionate dioxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H157N
-
over 3fold reduction in kcat/Km value
Y159F
-
3fold reduction in kcat/Km value. Fe coordination of cysteine is switched from thiolate only to bidentate (thiolate/amine) for the variant
G95C
variant is able to form a cysteine-tyrosine crosslink homologous to that found in mammalian cysteine dioxygenases. Activity of this variant is severely impaired
Q62R
variant retains both 3-mercaptopropanoate and cysteine dioxygenase activity
R168A
variant does not fold properly
R168C
variant does not fold properly
G95C
-
variant is able to form a cysteine-tyrosine crosslink homologous to that found in mammalian cysteine dioxygenases. Activity of this variant is severely impaired
-
Q62R
-
variant retains both 3-mercaptopropanoate and cysteine dioxygenase activity
-
R168A
-
variant does not fold properly
-
R168C
-
variant does not fold properly
-