1.13.11.87: endo-cleaving rubber dioxygenase
This is an abbreviated version!
For detailed information about endo-cleaving rubber dioxygenase, go to the full flat file.
Reaction
Cleavage of cis-1,4-polyisoprene polymers into a mixture of compounds, including a C20 compound ((4Z,8Z,12Z,16Z,20Z,24Z)-4,8,12,16,20,24-hexamethyl-28-oxononacosa-4,8,12,16,20,24-hexaenal), a C25 compound ((4Z,8Z,12Z,16Z,20Z)-4,8,12,16,20-pentamethyl-24-oxopentacosa-4,8,12,16,20-pentaenal), a C30 compound ((4Z,8Z,12Z,16Z)-4,8,12,16-tetramethyl-20-oxohenicosa-4,8,12,16-tetraenal), and larger isoprenologes such as C35, C40, C45, and higher analogues
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Synonyms
GPOL_174p00150, GPOL_c48310, latex clearing protein, latex-clearing protein, Lcp, Lcp protein, Lcp1, lcp1VH2, Lcp2, lcp2VH2, LcpK30, polyisoprene-cleaving rubber oxygenase, roxA, RoxB, rubber oxidizing protein, rubber oxygenase, rubber oxygenase B
ECTree
General Information
General Information on EC 1.13.11.87 - endo-cleaving rubber dioxygenase
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physiological function
synergistic effect of the simultaneous presence of RoxAXsp and RoxBXsp on the efficiency of polyisoprene cleavage
malfunction
after deletion of lcp2VH2 in the lcp1VH2 deletion mutant strain M71, the resulting double mutant strain C15 loses its ability to grow with cis-1,4-polyisoprene as the sole carbon source. A lcp2VH2 single-deletion mutant exhibits growth behavior on cis-1,4-polyisoprene very similar to that of the lcp1VH2 single-deletion mutant strain M71. Either of the two Lcp-encoding genes allows adhesive growth of Gordonia polyisoprenivorans strain VH2 on rubber
malfunction
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Gram-negative rubber-degrading bacteria generally utilise two synergistically acting rubber oxygenases (RoxA/RoxB) for efficient cleavage of polyisoprene to (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal
malfunction
knock out lcp mutant exhibits reduced growth in liquid mineral salts media containing poly(cis-1,4-isoprene) as the sole carbon and energy source
malfunction
the enzyme is involved in rubber degradation
malfunction
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the enzyme is involved in rubber degradation
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malfunction
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Gram-negative rubber-degrading bacteria generally utilise two synergistically acting rubber oxygenases (RoxA/RoxB) for efficient cleavage of polyisoprene to (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal
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malfunction
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after deletion of lcp2VH2 in the lcp1VH2 deletion mutant strain M71, the resulting double mutant strain C15 loses its ability to grow with cis-1,4-polyisoprene as the sole carbon source. A lcp2VH2 single-deletion mutant exhibits growth behavior on cis-1,4-polyisoprene very similar to that of the lcp1VH2 single-deletion mutant strain M71. Either of the two Lcp-encoding genes allows adhesive growth of Gordonia polyisoprenivorans strain VH2 on rubber
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metabolism
the enzyme is essential for the microbial utilization of rubber
metabolism
the enzyme is involved in degradation of rubber
metabolism
the enzyme is involved in rubber degradation
metabolism
the enzyme is involved in the initial cleavage of poly(cis-1,4-isoprene)
metabolism
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the synergistic action of the two rubber oxygenases RoxANS21 and RoxBNS21 enables the species to grow on polyisoprene latex as the sole source of carbon and energy
metabolism
the synergistic effect of the simultaneous presence of RoxA35Y and RoxB35Y enables the organism to convert rubber extracellularly at high efficiency to just one cleavage product of defined length ((4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal) that can be taken up by only one transport protein and can be used as a source of carbon and energy
metabolism
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
metabolism
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
metabolism
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
metabolism
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
metabolism
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
metabolism
-
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
metabolism
-
the synergistic action of the two rubber oxygenases RoxANS21 and RoxBNS21 enables the species to grow on polyisoprene latex as the sole source of carbon and energy
-
metabolism
-
the enzyme is involved in rubber degradation
-
metabolism
-
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
-
metabolism
-
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
-
metabolism
-
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
-
metabolism
-
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
-
metabolism
-
the enzyme is essential for the poly(cis-1,4-isoprene) rubber utilization of its host strain
-
metabolism
-
the enzyme is essential for the microbial utilization of rubber
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