1.13.11.79: 5,6-dimethylbenzimidazole synthase

This is an abbreviated version!
For detailed information about 5,6-dimethylbenzimidazole synthase, go to the full flat file.

Reaction

FMNH2
+
O2
=
5,6-Dimethylbenzimidazole
+
D-erythrose 4-phosphate
+
other product(s)

Synonyms

BluB, bluB/cobT2, DMB-synthase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.79 5,6-dimethylbenzimidazole synthase

Natural Substrates Products

Natural Substrates Products on EC 1.13.11.79 - 5,6-dimethylbenzimidazole synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
FMNH2 + NADH + H+ + O2 + alloxan
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + dialuric acid
show the reaction diagram
-
-
-
-
?
FMNH2 + O2
5,6-dimethylbenzimidazole + ?
show the reaction diagram
-
FMNH2 reacts with oxygen to yield flavin hydroperoxide, which then undergoes a ring expansion with loss of a water molecule to produce intermediate A. This disintegrates further as a result of four hydrolysis reactions in which it is attacked by water molecules. The resulting diaminobenzene product undergoes two oxidation reactions, to form 5,6-dimethylbenzimidazole
-
-
?
FMNH2 + O2
5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + urea + ?
show the reaction diagram