1.13.11.71: carotenoid-9',10'-cleaving dioxygenase

This is an abbreviated version!
For detailed information about carotenoid-9',10'-cleaving dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.71

Reaction

all-trans-beta-carotene
+
O2
=
all-trans-10'-apo-beta-carotenal
+
beta-ionone

Synonyms

BC-9',10'-oxygenase, Bcdo2, BCO2, beta,beta-carotene 9',10'-dioxygenase 2, beta,beta-carotene 9',10'-oxygenase, beta,beta-carotene-9',10'-dioxygenase, beta,beta-carotene-9,10-oxygenase 2, beta-carotene 9',10' oxygenase, beta-carotene 9',10'-oxygenase, beta-carotene-9',10'-oxygenase, beta-carotene-9,10'-oxygenase, CCD7, LjCCD7, ScBCO2, xanthophyll cleavage enzyme

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.71 carotenoid-9',10'-cleaving dioxygenase

Expression

Expression on EC 1.13.11.71 - carotenoid-9',10'-cleaving dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a marked up-regulation of Bcdo2 expression in inguinal white adipose tissue of Bcmo1-null mice is shown, both with control and beta-carotene diet
-
expression of the bco2 gene is dramatically decreased in prostate cancer tissue and in a range of prostate cancer cell lines as compared with nonneoplastic prostate tissue and normal prostatic epithelial cells, respectively. Inhibition of DNA methyltransferase activity restores bco2 expression in prostate cancer cell lines tested
-
treatment with lycopene or its metabolite, apo-10-lycopenal, increases bco2 expression and reduces cell proliferation in androgen-sensitive cell lines, but lycopene neither alters bco2 expression nor cell growth in androgen-resistant cells
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