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1.13.11.65: carotenoid isomerooxygenase

This is an abbreviated version!
For detailed information about carotenoid isomerooxygenase, go to the full flat file.

Word Map on EC 1.13.11.65

Reaction

zeaxanthin
+
O2
=
(3R)-11-cis-3-hydroxyretinal
+
(3R)-all-trans-3-hydroxyretinal

Synonyms

carotenoid cleavage oxygenase, CCO, CSO2, NinaB, ppsir_15490, Rv0654, sala_1698, SIR-1

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.65 carotenoid isomerooxygenase

Engineering

Engineering on EC 1.13.11.65 - carotenoid isomerooxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A49P
the catalytic efficiency of the mutant is 1.6fold that of the wild type enzyme. The mutant exhibits better thermostability than that of wild type. Under temperatures lower than 30°C, mutant A49P retains almost all the activities within the shorter incubation time (less than 5 h). The mutant also shows better performance even at 35°C
I234A
the mutant shows strongly decreased catalytic efficiency compared to the wild type enzyme
Q390A
the catalytic efficiency of the mutant is 1.64fold that of the wild type enzyme. The mutant exhibits better thermostability than that of wild type
A49P
-
the catalytic efficiency of the mutant is 1.6fold that of the wild type enzyme. The mutant exhibits better thermostability than that of wild type. Under temperatures lower than 30°C, mutant A49P retains almost all the activities within the shorter incubation time (less than 5 h). The mutant also shows better performance even at 35°C
-
I234A
-
the mutant shows strongly decreased catalytic efficiency compared to the wild type enzyme
-
Q390A
-
the catalytic efficiency of the mutant is 1.64fold that of the wild type enzyme. The mutant exhibits better thermostability than that of wild type
-