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1.13.11.63: beta-carotene 15,15'-dioxygenase

This is an abbreviated version!
For detailed information about beta-carotene 15,15'-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.63

Reaction

beta-carotene
+
O2
= 2 all-trans retinal

Synonyms

BC-15,15'-oxygenase, BCM, BCMO, Bcmo1, Bcmo2, BCO, BCO1, BCO2, Bcox, beta,beta-carotene 15,15'-mono-oxygenase 1, beta,beta-carotene 15,15'-monooxygenase, beta,beta-carotene 15,15'-monooxygenase 1, beta,beta-carotene 15,15'-monooxygenase-1, beta,beta-carotene 15,15-monooxygenase 1, beta,beta-carotene-15,15'-monooxygenase, beta,beta-carotene-15,15'-oxygenase, beta-carotene 15,15' oxygenase, beta-carotene 15,15'-dioxygenase, beta-carotene 15,15'-monooxygenase, beta-carotene 15,15'-monooxygenase 1, beta-carotene 15,15'-oxygenase, beta-carotene 15,15-monooxygenase, beta-carotene dioxygenase 1, beta-carotene oxygenase 2, beta-carotene-15,15'-dioxygenase, beta-carotene-15,15'-monooxygenase, beta-carotene-15,15'-oxygenase, beta-carotene-15,15'-oxygenase-1, beta-carotene-15,15'-oxygenase-2, beta-CD, betaCDIOX, betaCO, BLH, brp/blh-family beta-carotene monooxygenase, brpA, carotenoid oxygenase, Ci-BCO, CMO1, EC 1.13.11.21, EC 1.14.99.36, NinaB

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.63 beta-carotene 15,15'-dioxygenase

Expression

Expression on EC 1.13.11.63 - beta-carotene 15,15'-dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
addition of beta-carotene to the diet reduces the mRNA levels of BCMO1 in the liver in both genotypes, haplotypes AN57A and GN57G
-
endogenous nuclear HNF-1alpha and HNF-4alpha proteins competitively bind these sites in Caco-2 BBe cells. BCMO1 gene expression levels and promoter activity are significantly decreased in HNF-1alpha siRNA-transfected Caco-2 BBe cells. In contrast, HNF-4alpha siRNA-transfected cells exhibit a significant increase in BCMO1 gene expression and promoter activity. Mutation of these overlapping binding sites dramatically decreases BCMO1 promoter activity
expression of enzyme BCMO1 is lower in liver and intestine from dehydroepiandrosterone fed rats but higher in testis and unaffected in lung and kidney compared to controls
mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13, and 15
nitrofen increases maternal but not fetal Bcmo1,2 expression in the placenta in nitrofen-induced congenital diaphragmatic hernia, CDH, group. The markedly increased decidual Bcmo1,2 expression suggests that nitrofen may trigger local, decidual retinol synthesis in the nitrofen model of CDH
the enzyme expression is induced by Zn2+