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1.13.11.60: linoleate 8R-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 8R-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.60

Reaction

linoleate
+
O2
=
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate

Synonyms

5,8-LDS, 5,8-linoleate diol synthase, 6,8-diol synthase, 6R,8R-linoleate diol synthase, 6R,8RLDS, 7,8-diol synthase, 7,8-LDS, 7,8-linoleate diol synthase, 8(R)-dioxygenase, 8,11-hydroperoxide isomerase, 8-DOX, 8R-dioxygenase, 8R-DOX, 8R-DOX-5,8-LDS, 8R-DOX-7,8-LDS, 8R-DOX-LDS, dioxygenase-cytochrome P450, DOX-CYP, EC 1.13.11.44, EGE82165, FOXB_09952, GLRG_10013, linoleate 7,8-LDS, linoleate 8,11-LDS, linoleate diol synthase, linoleic acid 8R-dioxygenase, ODH51007, orphan DOX-CYP, PpoA

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.60 linoleate 8R-lipoxygenase

KM Value

KM Value on EC 1.13.11.60 - linoleate 8R-lipoxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0226
(11Z)-icos-11-enoic acid
pH 7.2, 24°C
0.0193
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
recombinant enzyme, whole enzyme activity, pH 6.5, 40°C
0.0264 - 0.0371
alpha-linolenate
0.0329
alpha-linolenic acid
-
full-length enzyme, at pH 6.5 and 25°C
0.0358
arachidonate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
0.0358
arachidonic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
0.0369
dihomo-gamma-linolenate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
0.0368
dihomo-gamma-linolenic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
0.0319
eicosadienoate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
0.0319
eicosadienoic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
0.0324
eicosenoate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
0.0324
eicosenoic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
0.008 - 0.022
linoleate
0.0264
linoleic acid
-
full-length enzyme, at pH 6.5 and 25°C
0.03
O2
pH 7.4 25°C
0.00671 - 0.0333
oleate
0.0283
oleic acid
-
full-length enzyme, at pH 6.5 and 25°C
0.005 - 0.048
palmitoleate
0.0475
palmitoleic acid
-
full-length enzyme, at pH 6.5 and 25°C
additional information
additional information
-