1.13.11.6: 3-hydroxyanthranilate 3,4-dioxygenase
This is an abbreviated version!
For detailed information about 3-hydroxyanthranilate 3,4-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.6
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1.13.11.6
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quinolinic
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kynureninase
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quin
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2,3-dioxygenase
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3-monooxygenase
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excitotoxin
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phosphoribosyltransferase
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kynurenine-oxoglutarate
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aminocarboxymuconate-semialdehyde
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kynurenic
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3-hydroxykynurenine
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ibotenic
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epilepsy-prone
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picolinic
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drug development
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medicine
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pharmacology
- 1.13.11.6
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quinolinic
- kynureninase
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quin
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2,3-dioxygenase
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3-monooxygenase
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excitotoxin
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phosphoribosyltransferase
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kynurenine-oxoglutarate
- aminocarboxymuconate-semialdehyde
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kynurenic
- 3-hydroxykynurenine
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ibotenic
-
epilepsy-prone
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picolinic
- drug development
- medicine
- pharmacology
Reaction
Synonyms
3-HAD, 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxidase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3HAO, EC 1.13.1.6, HAD, HAO, oxygenase, 3-hydroxyanthranilate 3,4-di-
ECTree
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Substrates Products
Substrates Products on EC 1.13.11.6 - 3-hydroxyanthranilate 3,4-dioxygenase
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REACTION DIAGRAM
2-amino-3-hydroxybenzoic acid + O2
2,3-pyridinedicarboxylic acid + H2O
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intermediate 2-amino-3-carboxymuconic acid semialdehyde
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?
4-ethyl-3-hydroxyanthranilate + O2
2-amino-3-carboxy-4-ethylmuconate semialdehyde
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-
-
?
4-methyl-3-hydroxyanthranilate + O2
2-amino-3-carboxy-4-methylmuconate semialdehyde
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-
-
?
4-propyl-3-hydroxyanthranilic acid + O2
2-amino-3-carboxy-4-propylmuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
the enzymatic product subsequently cyclizes to quinolinate
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?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
the enzyme employs loop dynamics to accommodate two substrates with disparate polarities
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-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
the enzyme employs loop dynamics to accommodate two substrates with disparate polarities
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-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
r
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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enzyme occurs in the metabolic pathway of the conversion of tryptophan to nicotinic acid
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-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
-
-
-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
-
-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
-
-
-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
-
-
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
-
-
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
-
-
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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high selectivity for substrate
reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+
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-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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biosynthetic enzyme of the endogenous excitotoxin quinolinic acid
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-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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-
-
-
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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reacts spontaneously to quinolinic acid
?
3-hydroxyanthranilate + O2
2-amino-3-carboxymuconate semialdehyde
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in the kynurenine pathway
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-
?
?
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no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
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-
?
additional information
?
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no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
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-
?
additional information
?
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no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
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-
?