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1.13.11.52: indoleamine 2,3-dioxygenase

This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.52

Reaction

D-tryptophan
+
O2
=
N-formyl-D-kynurenine

Synonyms

31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.52 indoleamine 2,3-dioxygenase

Specific Activity

Specific Activity on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000011
-
pulmonary IDO activity in pneumothorax patients
0.000014
-
pulmonary IDO activity in benign tumor patient
0.000015
-
pulmonary IDO activity in tuberculosis patient
0.000039
-
pulmonary IDO activity in bronchiectasis patient
0.00005
-
pulmonary IDO activity in lung cancer patients
0.000067
-
pulmonary IDO activity in pulmonary abscess patient
0.000192
-
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment
0.000208
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment
0.000224
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with neomycin
0.000245
-
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone
0.000256
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone
0.000272
-
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan
0.000277
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan
0.00033
-
crude extract of human lung slices treated with gamma-IFN
0.000598
-
supernatant, 0.8 mM L-tryptophan, 40 mM ascorbic acid, 0.02 mM methylene blue, 200 units/ml catalase, 100 mM potassium phosphate buffer, pH 6.5, 37°C, 30 min
0.011
-
brain, in air, 50 mM potassium phosphate buffer, pH 6.5, 0.025 mM methylene blue, 20 mM ascorbate, 0.05 mM catalase, 0.4 mM L-tryptophan, 37°C
0.014
-
brain, in 1.2 atm oxygen, 50 mM potassium phosphate buffer, pH 6.5, 0.025 mM methylene blue, 20 mM ascorbate, 0.05 mM catalase, 0.4 mM L-tryptophan, 37°C
0.022
-
sample 14 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.024
-
sample 17 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.04
-
small intestine IV, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
0.05
-
small intestine proximal portion, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
0.072
-
assuming an average wet weight of the lens of 0.2 g, assay in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg/ml catalase, 0.4 mM L-tryptophan, 90 min, 37°C
0.08
-
appendix, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
0.122
-
submandibular gland
0.13
-
testis
0.145
-
small intestine, in 5.2 atm oxygen, 50 mM potassium phosphate buffer, pH 6.5, 0.025 mM methylene blue, 20 mM ascorbate, 0.05 mM catalase, 0.4 mM L-tryptophan, 37°C
0.15
-
appendix, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
0.155
-
kidney
0.165
-
brain
0.183
-
heart
0.198
-
lung, in air, 50 mM potassium phosphate buffer, pH 6.5, 0.025 mM methylene blue, 20 mM ascorbate, 0.05 mM catalase, 0.4 mM L-tryptophan, 37°C
0.232
-
brain, lipopolysaccharide-treated mice
0.278
-
esophagus, lipopolysaccharide-treated mice
0.342
-
submandibular gland, lipopolysaccharide-treated mice
0.375
-
stomach
0.425
-
thymus
0.45
-
lung
0.468
-
cecum
0.474
-
sample 11 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.479
-
sample 19 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.55
-
25°C, 50 mM HEPES/NaOH (pH 7.3), 5 mM D-tryptophan 0.01 mM methylene blue, 5 mM ascorbic acid, 0.001 mM catalase
0.56
-
testis, lipopolysaccharide-treated mice
0.57
-
heart, lipopolysaccharide-treated mice
0.636
-
sample 15 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.689
-
sample 21 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.72
-
seminal vesicle
0.735
-
trachea, lipopolysaccharide-treated mice
0.755
-
spleen, lipopolysaccharide-treated mice
0.8
-
thymus, lipopolysaccharide-treated mice
0.873
-
lung, in 5.2 atm oxygen, 50 mM potassium phosphate buffer, pH 6.5, 0.025 mM methylene blue, 20 mM ascorbate, 0.05 mM catalase, 0.4 mM L-tryptophan, 37°C
0.903
-
colon
0.905
-
lung, in 1.2 atm oxygen, 50 mM potassium phosphate buffer, pH 6.5, 0.025 mM methylene blue, 20 mM ascorbate, 0.05 mM catalase, 0.4 mM L-tryptophan, 37°C
0.913
-
sample 13 of 22 cervical mucus sampples, determined by HPLC/UV detection, reaction mixture include 0.025 mM methylene blue, 20 mM ascorbic acid, 0.04 mM L-tryptophan solution, 0.05 ml catalase and 50 mM potassium phosphate buffer (pH 6.5), 30 min, 37°C
0.92
-
spleen
0.968
-
trachea
1.39
-
urinary bladder, lipopolysaccharide-treated mice
1.455
-
urinary bladder
1.902
-
stomach, lipopolysaccharide-treated mice
104.9
-
epididymis, lipopolysaccharide-treated mice
12.5
-
cells grown on L-alanine
15.31
-
cecum, lipopolysaccharide-treated mice
15.6
-
cells grown on L-asparagine
2.017
-
intestine
2.13
-
25°C, 50 mM HEPES/NaOH (pH 7.3), 2 mM L-tryptophan 0.01 mM methylene blue, 5 mM ascorbic acid, 0.001 mM catalase
2.48
-
kynurenine, 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid, 0.2 mg/ml catalase, 0.01 mM methylene blue, 0.4 mM tryptophan, 37°C, 10-60 min
2.58
-
-
22.7
-
cells grown on L-tryptophan
23.5
-
cells grown on L-arginine
234
-
enzyme after purification, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
26.68
-
colon, lipopolysaccharide-treated mice
32.22
-
epididymis
4.07
-
intestine, lipopolysaccharide-treated mice
5.19
-
small intestine VI, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
5.34
-
lung, lipopolysaccharide-treated mice
6.97
-
small intestine distal portion, 0.05 mM potassium phosphate buffer (pH 7.5), 0.005 mM methylene blue, 0.01 mM ascorbic acid, 0.003 mM tryptophan, 37°C
8.33
-
seminal vesicle, lipopolysaccharide-treated mice
additional information