1.13.11.52: indoleamine 2,3-dioxygenase
This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.52
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1.13.11.52
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kynurenine
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dendritic
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t-cells
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lymphocyte
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immunotherapy
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ifn-gamma
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immunomodulatory
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autoimmune
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mesenchymal
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interferon-gamma
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tregs
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allogeneic
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immunoregulatory
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rejection
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serotonin
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heme
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monocyte
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tolerogenic
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quinolinic
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checkpoint
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neopterin
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allograft
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immunomodulation
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foxp3
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antigen-presenting
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immunoregulation
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myeloid-derived
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3-hydroxykynurenine
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ctla-4
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graft-versus-host
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l-trp
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3-hydroxyanthranilic
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quin
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tumor-infiltrating
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heme-containing
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depressive-like
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immunotherapeutic
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plasmacytoid
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5-hydroxytryptamine
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monocyte-derived
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ifn-gamma-induced
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5-hydroxyindoleacetic
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interferon-gamma-induced
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immuno-oncology
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drug development
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cd4+cd25+foxp3+
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mdscs
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pharmacology
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alloreactive
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3-monooxygenase
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ifn-gamma-mediated
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medicine
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death-ligand
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synthesis
- 1.13.11.52
- kynurenine
- dendritic
- t-cells
- lymphocyte
-
immunotherapy
- ifn-gamma
-
immunomodulatory
- autoimmune
- mesenchymal
- interferon-gamma
-
tregs
-
allogeneic
-
immunoregulatory
-
rejection
- serotonin
- heme
- monocyte
-
tolerogenic
-
quinolinic
-
checkpoint
- neopterin
-
allograft
-
immunomodulation
- foxp3
-
antigen-presenting
-
immunoregulation
-
myeloid-derived
- 3-hydroxykynurenine
-
ctla-4
- graft-versus-host
- l-trp
-
3-hydroxyanthranilic
-
quin
-
tumor-infiltrating
-
heme-containing
-
depressive-like
-
immunotherapeutic
-
plasmacytoid
- 5-hydroxytryptamine
-
monocyte-derived
-
ifn-gamma-induced
-
5-hydroxyindoleacetic
-
interferon-gamma-induced
-
immuno-oncology
- drug development
-
cd4+cd25+foxp3+
-
mdscs
- pharmacology
-
alloreactive
-
3-monooxygenase
-
ifn-gamma-mediated
- medicine
-
death-ligand
- synthesis
Reaction
Synonyms
31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein
ECTree
1.13.11.52 indoleamine 2,3-dioxygenaseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 1.13.11.52 - indoleamine 2,3-dioxygenase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
alpha-methyl-DL-tryptophan
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can activate the enzyme when lower concentrations of L-Trp are used
Cys
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can reduce the inactive ferric form of the enzyme to the active ferrous form
DTT
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can reduce the inactive ferric form of the enzyme to the active ferrous form
ethylhydroperoxide
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can reduce the inactive ferric form of the enzyme to the active ferrous form
GSH
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can reduce the inactive ferric form of the enzyme to the active ferrous form
hydrogen peroxide
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activates the peroxidase function of IDO to induce protein oxidation and inhibit dioxygenase activity
methylhydroperoxide
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can reduce the inactive ferric form of the enzyme to the active ferrous form
superoxide
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the enzyme is inactive unless superoxide anion is present, the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme
alpha-interferon
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induces de novo synthesis of IDO, but 2 to 3 orders of magnitude less than gamma-IFN
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ascorbic acid
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native and recombinant enzyme require methylene blue and ascorbic acid for activity
ascorbic acid
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the ferric enzyme is incapable of catalyzing the reaction but is reduced to an active ferrous form by the addition of ascorbic acid and L-Trp in presence of O2
ascorbic acid
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tryptophan 2,3-dioxygenase: maximal activity at 10 mM ascorbate
gamma-interferon
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induces de novo synthesis of IDO, 30fold increase in IDO activity
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H2O2
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hydrogen peroxide-triggered enzyme reactivation from the resting ferric oxidation state to the catalytically active ferrous form, modeling, overview
H2O2
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can reduce the inactive ferric form of the enzyme to the active ferrous form
methylene blue
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native and recombinant enzyme require methylene blue and ascorbic acid for activity
methylene blue
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no activity without, half-maximal activity at 0.002 mM
methylene blue
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acts as electron mediator from donors to the ferric dioxygenase
additional information
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aerobically photoactivation as well as anaerobically by light of wavelength less than 360 nm, the substrate, L-Trp must be present for photoactivation to proceed, 6-fluorotryptophan can mediate photoactivation
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additional information
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reactive oxygen intermediates are dispensable for indoleamine 2,3-dioxygenase activity
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additional information
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the enzyme can be activated through different pathways either by superoxide anion or by an electron donor-methylene blue system where the dye is acting as an electron mediator from the donor to the ferric dioxygenase
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additional information
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IDO can bind following substances as ligand in effector binding site: alkyl isocyanides, CN-, F-, N3-, imidazoles, pyridines, formate, benzhydroxamate, phosphines
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additional information
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not induced by either tryptophan or glucocorticoid
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additional information
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requires molecular oxygen and superoxide anion
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additional information
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kynurenine induces both tryptophan oxygenase and kynureninase of the catabolic pathway of L-tryptophan degradation
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