1.13.11.50: acetylacetone-cleaving enzyme

This is an abbreviated version, for detailed information about acetylacetone-cleaving enzyme, go to the full flat file.

Reaction

Pentane-2,4-dione
+
O2
=
acetate
+
methylglyoxal

Synonyms

acetylacetone dioxygenase, acetylacetone-cleaving enzyme, b-diketone dioxygenase, cupin-type dioxygenase, diketone cleaving dioxygenase, diketone cleaving enzyme, diketone dioxygenase, diketone-cleaving dioxygenase, diketone-cleaving enzyme, Dke1, oxygenase, b-diketone di-, pentane-2,4-dione hydrolase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.50 acetylacetone-cleaving enzyme

Reference

Reference on EC 1.13.11.50 - acetylacetone-cleaving enzyme

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Straganz, G.D.; Glieder, A.; Brecker, L.; Ribbons, D.W.; Steiner, W.
Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii
Biochem. J.
369
573-581
2003
Acinetobacter johnsonii
Manually annotated by BRENDA team
Straganz, G.; Brecker, L.; Weber, H.J.; Steiner, W.; Ribbons, D.W.
A novel beta-diketone-cleaving enzyme from Acinetobacter johnsonii: acetylacetone 2,3-oxygenase
Biochem. Biophys. Res. Commun.
297
232-236
2002
Acinetobacter johnsonii
Manually annotated by BRENDA team
Hofer, H.; Steiner, W.
Fast determination of operational stability of the soluble acetylacetone-cleaving enzyme Dke1 in an enzyme membrane reactor
Appl. Microbiol. Biotechnol.
1
1-12
2005
Acinetobacter johnsonii
Manually annotated by BRENDA team
Grogan, G.
Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage
Biochem. J.
388
721-730
2005
Acinetobacter johnsonii
Manually annotated by BRENDA team
Straganz, G.; Slavica, A.; Hofer, H.; Mandl, U.; Steiner, W.; Nidetzky, B.
Integrated approach for production of recombinant acetylacetone dioxygenase from Acinetobacter johnsonii
Biocatal. Biotransform.
23
261-269
2005
Acinetobacter johnsonii
-
Manually annotated by BRENDA team
Straganz, G.D.; Nidetzky, B.
Reaction coordinate analysis for beta-diketone cleavage by the non-heme Fe2+-dependent dioxygenase Dke1
J. Am. Chem. Soc.
127
12306-12314
2005
Acinetobacter johnsonii
Manually annotated by BRENDA team
Straganz, G.D.; Egger, S.; Aquino, G.; DAuria, S.; Nidetzky, B.
Exploring the cupin-type metal-coordinating signature of acetylacetone dioxygenase Dke1 with site-directed mutagenesis: Catalytic reaction profile and Fe2+ binding stability of Glu-69->Gln mutant
J. Mol. Catal. B
39
171-178
2006
Acinetobacter johnsonii
-
Manually annotated by BRENDA team
Leitgeb, S.; Straganz, G.D.; Nidetzky, B.
Biochemical characterization and mutational analysis of the mononuclear non-haem Fe2+ site in Dke1, a cupin-type dioxygenase from Acinetobacter johnsonii
Biochem. J.
418
403-411
2009
Acinetobacter johnsonii, Acinetobacter johnsonii (Q8GNT2)
Manually annotated by BRENDA team
Diebold, A.R.; Neidig, M.L.; Moran, G.R.; Straganz, G.D.; Solomon, E.I.
The three-his triad in Dke1: comparisons to the classical facial triad
Biochemistry
49
6945-6952
2010
Acinetobacter johnsonii
Manually annotated by BRENDA team
Straganz, G.D.; Diebold, A.R.; Egger, S.; Nidetzky, B.; Solomon, E.I.
Kinetic and CD/MCD spectroscopic studies of the atypical, three-His-ligated, non-heme Fe2+ center in diketone dioxygenase: the role of hydrophilic outer shell residues in catalysis
Biochemistry
49
996-1004
2010
Acinetobacter johnsonii (Q8GNT2)
Manually annotated by BRENDA team
Diebold, A.R.; Straganz, G.D.; Solomon, E.I.
Spectroscopic and computational studies of alpha-keto acid binding to Dke1: understanding the role of the facial triad and the reactivity of beta-diketones
J. Am. Chem. Soc.
133
15979-15991
2011
Acinetobacter johnsonii
Manually annotated by BRENDA team
Brkic, H.; Buongiorno, D.; Ramek, M.; Straganz, G.; Tomic, S.
Dke1--structure, dynamics, and function: a theoretical and experimental study elucidating the role of the binding site shape and the hydrogen-bonding network in catalysis
J. Biol. Inorg. Chem.
17
801-815
2012
Acinetobacter johnsonii
Manually annotated by BRENDA team
Brkic, H.
Insight of the iron binding and transport in Dke1 - A molecular dynamics study
Croat. Chem. Acta
88
297-306
2015
Acinetobacter johnsonii (Q8GNT2)
-
Manually annotated by BRENDA team