1.13.11.5: homogentisate 1,2-dioxygenase
This is an abbreviated version!
For detailed information about homogentisate 1,2-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.5
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1.13.11.5
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alkaptonuria
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ochronosis
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urine
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joint
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cartilage
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arthropathy
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sclera
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nitisinone
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arthroplasty
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discoloration
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darken
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maleylacetoacetate
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melanin-like
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calculi
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pyomelanin
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ultra-rare
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4-hydroxyphenylpyruvate
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slovakia
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medicine
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ntbc
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diagnostics
- 1.13.11.5
- alkaptonuria
-
ochronosis
- urine
- joint
- cartilage
- arthropathy
- sclera
- nitisinone
-
arthroplasty
-
discoloration
-
darken
- maleylacetoacetate
-
melanin-like
-
calculi
-
pyomelanin
-
ultra-rare
- 4-hydroxyphenylpyruvate
-
slovakia
- medicine
- ntbc
- diagnostics
Reaction
Synonyms
EC 1.13.1.5, EC 1.99.2.5, ElHDO, HgD, HGDO, HGO, HGOa, HGOb, HmgA, homogentisate 1,2 dioxigenase, homogentisate 1,2 dioxygenase, homogentisate 1,2-dioxygenase, homogentisate dioxygenase, homogentisate oxidase, homogentisate oxygenase, homogentisate phytyl-transferase, homogentisic acid 1,2-dioxygenase, homogentisic acid oxidase, homogentisic acid oxygenase, homogentisic oxygenase, homogentisicase, HPT, HTO
ECTree
1.13.11.5 homogentisate 1,2-dioxygenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.13.11.5 - homogentisate 1,2-dioxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-chlorohomogentisate + O2
3-chloro-4-maleylacetoacetate
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1% of activity with homogentisate
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-
?
3-methylhomogentisate + O2
3-methyl-4-maleylacetoacetate
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10% of activity with homogentisate
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-
?
homogentisate + O2
4-fumarylacetoacetate
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homogentisic acid is oxidatively cleaved between carbons 1 and 2 to yield 4-fumarylacetoacetic acid, enzyme requires high oxygen tension for maximal activity
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?
homogentisate + O2
4-maleylacetoacetate
Agave toumeyana
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homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
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-
?
homogentisate + O2
4-maleylacetoacetate
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homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
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highly specific for homogentisate
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?
homogentisate + O2
4-maleylacetoacetate
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one of the enzymes mediating phenylalanine catabolism
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-
?
homogentisate + O2
4-maleylacetoacetate
catalyzes an essential step in phenylalanine catabolism
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-
?
homogentisate + O2
4-maleylacetoacetate
catalyzes an essential step in phenylalanine catabolism
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-
?
homogentisate + O2
4-maleylacetoacetate
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specific for homogentisate
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?
homogentisate + O2
4-maleylacetoacetate
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one of the key enzymes involved in catabolism of phenylalanine, tyrosine, phenylacetic acid and hydroxyphenylacetic acids
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-
?
homogentisate + O2
4-maleylacetoacetate
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specific for homogentisate
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?
homogentisate + O2
4-maleylacetoacetate
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one of the key enzymes involved in catabolism of phenylalanine, tyrosine, phenylacetic acid and hydroxyphenylacetic acids
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-
?
homogentisate + O2
4-maleylacetoacetate
Coleus scutellarioides
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homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
ElHDO expression is induced during growth on ethylbenzene
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-
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
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utilizes a nonheme iron to incorporate both atoms of molecular oxygen into homogentisate, identical with 2,5-dihydroxyphenylacetate
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?
homogentisate + O2
4-maleylacetoacetate
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enzyme catalyzes an intermediate step in the catabolism of tyrosine and phenylalanine
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-
?
homogentisate + O2
4-maleylacetoacetate
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enzyme cleaves the aromatic ring during the metabolic degradation of phenylalanine and tyrosine
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-
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
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homogentisate is the natural substrate, key reaction in the catabolic pathway of aromatic amino acids, oxidative cleavage of the aromatic ring
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ir
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
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specific for homogentisate
-
?
homogentisate + O2
4-maleylacetoacetate
-
-
product is 4-maleylacetoacetate, which is converted by a specific cis-trans isomerase to 4-fumarylacetoacetate
?
homogentisate + O2
4-maleylacetoacetate
-
homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate
-
-
?
homogentisate + O2
4-maleylacetoacetate
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hmgA is necessary for tyrosine catabolism and the proper production of actinorhodin. Transcription of hmgA is activated by HpdA in the presence of tyrosine
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-
?
additional information
?
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not as substrates: phenylacetate, 2-hydroxyphenylacetate, 3-hydroxyphenylacetate, 4-hydroxyphenylacetate, phenylalanine, tyrosine, phenylpyruvate, gentisate
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-
?
additional information
?
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enzyme structure, conformation of the active site, enzyme contains a 280-residue N-terminal domain and a 140-residue C-terminal domain, associated as a hexamer arranged as a dimer of trimers
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-
?
additional information
?
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LB400 cells grown with 3-hydroxyphenylacetate degrade homogentisate and show homogentisate 1,2-dioxygenase, EC 1.13.11.5 activity
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-
?
additional information
?
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growth of the hmgA mutant on L-tyrosine as sole carbon and energy sources is impaired. Growth on L-tyrosine is restored and production of the brown melanin pigment is eliminated when the mutant is complemented with the wild-type hmgA gene. The change in aromatic amino acids metabolism caused by the deletion of the hmgA gene function does not impair production of phenazines and biological traits connected to these secondary compounds: inhibition of fungal growth and inhibition of barley seed germination
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-
?
additional information
?
-
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growth of the hmgA mutant on L-tyrosine as sole carbon and energy sources is impaired. Growth on L-tyrosine is restored and production of the brown melanin pigment is eliminated when the mutant is complemented with the wild-type hmgA gene. The change in aromatic amino acids metabolism caused by the deletion of the hmgA gene function does not impair production of phenazines and biological traits connected to these secondary compounds: inhibition of fungal growth and inhibition of barley seed germination
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-
?
additional information
?
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not as substrates: salicylic acid, catechol, 2,3-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2,6-dihydroxybenzoic acid, o-hydroxyphenylacetic acid, p-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid
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-
?
additional information
?
-
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enzyme contains essential sulfhydryl groups
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-
?
