1.13.11.49: chlorite O2-lyase
This is an abbreviated version!
For detailed information about chlorite O2-lyase, go to the full flat file.
Word Map on EC 1.13.11.49
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1.13.11.49
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perchlorate
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chlorate
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dechloromonas
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perchlorate-reducing
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dismutases
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clo2
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dismutation
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high-spin
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low-spin
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dechloratans
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defluvii
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chlorate-reducing
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nitrospira
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ideonella
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aromatica
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azospira
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hemqs
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environmental protection
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molecular biology
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biotechnology
- 1.13.11.49
- perchlorate
- chlorate
- dechloromonas
-
perchlorate-reducing
- dismutases
- clo2
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dismutation
-
high-spin
-
low-spin
- dechloratans
- defluvii
-
chlorate-reducing
- nitrospira
- ideonella
- aromatica
- azospira
-
hemqs
- environmental protection
- molecular biology
- biotechnology
Reaction
Synonyms
chlorite dismutase, CLD, Cyan7425_1434, dimutase, chlorite, HemQ, Pfam chlorite dismutase, PitA
ECTree
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Inhibitors
Inhibitors on EC 1.13.11.49 - chlorite O2-lyase
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2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
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substrate inhibition at higher concentrations over 0.2 mM
H2O2
Stutzerimonas chloritidismutans
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at 70 microM 6% inhibition, at 700 microM 37% inhibition
azide
Stutzerimonas chloritidismutans
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at 70 microM 44% inhibition, at 700 microM 89% inhibition
chloride
upon cooperative binding of Cl-, Cld remains pentacoordinate and high-spin
chloride
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cooperative binding of Cl- to Cld drives formation of a hexacoordinate, high-spin aqua heme
chloride
weak mixed inhibitor that modifies the EPR signal of as-prepared samples
Chlorite
above 0.1 mM chlorite (5000fold excess) irreversible inactivation is observed
Chlorite
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irreversibly inactivates the enzyme after 17000 turnovers (per heme) and with a half-life of 0.39 min, resulting in bleaching of the heme chromophore. Guaiacol offers incomplete protection of the enzyme from inactivation
Chlorite
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chlorite acts a suicide substrate. Loss of activity is correlated with destruction of the heme and also some degree of protein damage
cyanide
Stutzerimonas chloritidismutans
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at 70 microM 83% inhibition, at 700 microM 95% inhibition
Stutzerimonas chloritidismutans
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at 70 microM 13% inhibition, at 700 microM 30% inhibition
fluoride coordinates to the heme iron in Cld exhibiting ny(FeIII-F) band at 390 per cm. Strong H-bond donation happens to the F- ligand
fluoride
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fluoride coordinates to the heme iron in Cld exhibiting ny(FeIII-F) band at 385 per cm. Strong H-bond donation happens to the F- ligand
additional information
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no product inhibition by O2 or chloride at millimolar concentrations
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additional information
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suicide inactivation by oxidative heme destruction
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additional information
Stutzerimonas chloritidismutans
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excess chlorite inactivates and bleaches the enzyme, 80% activity loss with 56 mM chlorite, 90% after second application of 56 mM chlorite; no inhibition by hydroxylamine or 3-amino-1,2,3-triazole
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