1.13.11.48: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

This is an abbreviated version, for detailed information about 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase, go to the full flat file.

Reaction

3-hydroxy-2-methyl-1H-quinolin-4-one
+
O2
=
N-acetylanthranilate
+
CO

Synonyms

1H-3-Hydroxy-4-oxoquinaldine 2,4-dioxygenase, 1H-3-hydroxy-4-oxoquinaldine oxygenase, 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase, HOD, HodC, More

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.48 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.48 - 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
1 mM, weak inhibition
Co2+
-
1 mM, weak inhibition
Cu2+
-
1 mM, strong inhibition
Fe2+
-
1 mM, strong inhibition
guanidine hydrochloride
Q7WSQ7;
almost linear decrease of activity up to 1 M where activity vanishes, three-state unfolding of mutant enzyme; causes isothermal unfolding of mutant C69S in a three-state mechanism, thermodynamic analysis, overview
Mg2+
-
1 mM, weak inhibition
Mn2+
-
1 mM, weak inhibition
Ni2+
-
1 mM, strong inhibition
Urea
Q7WSQ7;
causes isothermal unfolding of mutant C69S in a three-state mechanism, thermodynamic analysis, overview; nonlinear decrease of activity, activity lost at about 5 M, three-state unfolding of mutant enzyme
Zn2+
-
1 mM, strong inhibition