1.13.11.33: arachidonate 15-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 15-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.33
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1.13.11.33
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lipoxygenases
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cox-2
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15-hete
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polyunsaturated
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leukotriene
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eicosanoids
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hydroperoxide
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12-lipoxygenase
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cyclooxygenases
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lipoxins
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15s-hydroxyeicosatetraenoic
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ndga
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alox15b
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12/15-lipoxygenase
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nordihydroguaiaretic
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pro-resolving
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lipoxygenation
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resolvins
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hodes
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13-hydroxyoctadecadienoic
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lipid-peroxidating
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leukocyte-type
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oxylipins
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platelet-type
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medicine
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protectins
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drug development
- 1.13.11.33
- lipoxygenases
- cox-2
- 15-hete
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polyunsaturated
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leukotriene
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eicosanoids
- hydroperoxide
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12-lipoxygenase
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cyclooxygenases
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lipoxins
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15s-hydroxyeicosatetraenoic
- ndga
- alox15b
- 12/15-lipoxygenase
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nordihydroguaiaretic
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pro-resolving
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lipoxygenation
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resolvins
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hodes
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13-hydroxyoctadecadienoic
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lipid-peroxidating
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leukocyte-type
- oxylipins
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platelet-type
- medicine
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protectins
- drug development
Reaction
Synonyms
12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-LO, 12/15-LOX, 12/15LO, 15(S)-lipoxygenase-1, 15-hLO, 15-hLO-1, 15-hLO-2, 15-lipoxygenase, 15-lipoxygenase 1, 15-lipoxygenase 2, 15-lipoxygenase type 1, 15-lipoxygenase type 2, 15-lipoxygenase type-1, 15-lipoxygenase-1, 15-lipoxygenase-2, 15-lipoxygenase-I, 15-LO, 15-LO-1, 15-LO-2, 15-LO-I, 15-LOX, 15-LOX type 1, 15-LOX-1, 15-LOX-2, 15-LOX-A, 15-LOX2, 15-rLO, 15-rLO-1, 15-sLO, 15LO1, 15S-lipoxygenase, 15S-LOX1, ALOX12, Alox15, ALOX15-2, ALOX15B, arachidonate 12/15-lipoxygenase, arachidonate 15-lipoxygenase, arachidonate 15-lipoxygenase-1, arachidonic acid 15-lipoxygenase, arachidonic acid 15-lipoxygenase-1, cardiac 12/15-LOX, endothelial 15-lipoxygenase-1, epidermis-type 15-LOX, human prostate epithelial 15-lipoxygenase-2, linoleic acid omega-6-lipoxygenase, lipoxygenase L-1, lipoxygenase-1, LO-1, LOX-1, LOX2, LOX2:Hv:1, LoxA, More, omega-6 lipoxygenase, oxygenase, arachidonate 15-lip-, reticulocyte 15-lipoxygenase-1, reticulocyte 15-LOX, reticulocyte-type 15-human lipoxygenase, reticulocyte-type 15-lipoxygenase, reticulocyte-type 15-LO-1, reticulocyte-type of 15-LOX-1, SLO, soybean 15-lipoxygenase, soybean lipoxygenase-3
ECTree
1.13.11.33 arachidonate 15-lipoxygenaseAdvanced search results
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Source Tissue on EC 1.13.11.33 - arachidonate 15-lipoxygenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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expression, but no activity of 15-LOX in leukemic blasts induced by a Ca2+ ionophore, from acute myeloid leukemic and acute lymphoid leukemic patients, overview, quantitative expression analysis
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higher expression of 15-LO-1 compared with ostheoarthritis synovial tissue
additional information
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12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis
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12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis
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increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain
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increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain
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15-lipoxygenase activity is 100fold greater in eosinophils than in neutrophils
eosinophils are the major cell type expressing 12/15-LOX during the corneal wound healing process
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airway, high expression in airway epithelial cells, medium expression in cornea epithelial cells
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in airway epithelial cells, 15LO1 expression increases with asthma severity and correlates with MUC5AC expression
expression of 12/15-LOX pathway is upregulated in the diabetic heart
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2 isoenzymes detected in leukocytes, the minor isoenzyme is enriched in leukocytes from an eosinophilic patient
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isozyme 15-LO-1, differentiated monocytes obtained from human venous blood, CD14+
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12/15-LOX is a macrophage-selective regulator of interleukin-12 production
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12/15-LOX is expressed by 95% of resident peritoneal CD11bhigh cells, with the remaining 5% being 12/15-LOX-. 12/15-LOX+ cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX- cells are a dendritic cell population. Resident peritoneal macrophage numbers are significantly increased in 12/15-LOX-/- mice, suggesting alterations in migratory trafficking or cell differentiation in vivo
high level expression in peritoneal macrophages, while murine peripheral monocytes, alveolar macrophages and bone marrow-derived macrophages express alox15 only at low levels
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12/15-LOX is a macrophage-selective regulator of interleukin-12 production
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12/15-LOX is expressed by 95% of resident peritoneal CD11bhigh cells, with the remaining 5% being 12/15-LOX-. 12/15-LOX+ cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX- cells are a dendritic cell population. Resident peritoneal macrophage numbers are significantly increased in 12/15-LOX-/- mice, suggesting alterations in migratory trafficking or cell differentiation in vivo
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primary cortical neurons, increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain
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primary cortical neurons, increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-hydroperoxyicosatetraenoate and 15(S)-hydroperoxyicosatetraenoate in ischemic brain
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15-lipoxygenase 2, 15-LOX2, is down-regulated in prostate cancers compared with normal and benign prostate tissues
epithelial cells, 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal prostate epithelial cells, 15-LOX2 is positively regulated by Sp1 and negatively regulated by Sp3, overview
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639237, 639238, 639239, 639244, 639255, 639258, 639259, 639266, 657880, 658046, 658263, 671666, 671670, 672574, 685330, 702247, 706579
additional information
15-LOX2 expression is decreased or lost in high-grade prostate intraepithelial neoplasia and prostate cancer PCa cells
additional information
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15-LOX2 expression is decreased or lost in high-grade prostate intraepithelial neoplasia and prostate cancer PCa cells
additional information
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15-LOX-1 and -2 are preferentially expressed in normal tissue, present in HTB-38 cells
additional information
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15-LOX-2 is almost undetectable in parental head-and-neck cancer cell lines FaDu and UMSCC-1
additional information
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high expression in L-1236 cells (Hodgkin Reed-Sternberg cells), present in HDLM2 cells and KMH2 cells
additional information
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high expression in L-1236 cells (Hodgkin ReedSternberg cells), low expression in seminal fluid
additional information
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present in SF cells of rheumatoid arthritis tissue, absent in CD3+ T cells or in CD20+ B cells of rheumatoid arthritis tissue
additional information
tissue specific expression of ALOX15 and transcriptional expression regulation, overview. In humans ALOX15 is constitutively expressed at high levels in immature red blood cells, in eosinophils and in airway epithelial cells. Human peripheral blood monocytes do not express ALOX15
additional information
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tissue specific expression of ALOX15 and transcriptional expression regulation, overview. In humans ALOX15 is constitutively expressed at high levels in immature red blood cells, in eosinophils and in airway epithelial cells. Human peripheral blood monocytes do not express ALOX15
additional information
tissue specific expression of ALOX15 and transcriptional expression regulation, overview
additional information
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tissue specific expression of ALOX15 and transcriptional expression regulation, overview
additional information
stroma-free hemolysis supernatant of a reticulocyte-rich blood cell suspension
additional information
tissue specific expression of ALOX15 and transcriptional expression regulation, overview
additional information
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tissue specific expression of ALOX15 and transcriptional expression regulation, overview
additional information
tissue specific expression of ALOX15 and transcriptional expression regulation, overview
