1.13.11.33: arachidonate 15-lipoxygenase

This is an abbreviated version, for detailed information about arachidonate 15-lipoxygenase, go to the full flat file.

Reaction

arachidonate
+
O2
=
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Synonyms

12/15 lipoxygenase, 12/15-lipoxygenase, 12/15-LO, 12/15-LOX, 12/15LO, 15(S)-lipoxygenase-1, 15-hLO, 15-hLO-1, 15-hLO-2, 15-lipoxygenase, 15-lipoxygenase 1, 15-lipoxygenase 2, 15-lipoxygenase type 1, 15-lipoxygenase type 2, 15-lipoxygenase type-1, 15-lipoxygenase-1, 15-lipoxygenase-2, 15-lipoxygenase-I, 15-LO, 15-LO-1, 15-LO-2, 15-LO-I, 15-LOX, 15-LOX type 1, 15-LOX-1, 15-LOX-2, 15-LOX-A, 15-LOX2, 15-rLO, 15-rLO-1, 15-sLO, 15LO1, 15S-lipoxygenase, 15S-LOX1, Alox15, ALOX15-2, ALOX15B, arachidonate 12/15-lipoxygenase, arachidonate 15-lipoxygenase, arachidonate 15-lipoxygenase-1, arachidonic acid 15-lipoxygenase, arachidonic acid 15-lipoxygenase-1, cardiac 12/15-LOX, endothelial 15-lipoxygenase-1, epidermis-type 15-LOX, human prostate epithelial 15-lipoxygenase-2, linoleic acid omega-6-lipoxygenase, lipoxygenase L-1, lipoxygenase-1, LO-1, LOX-1, LOX2, LOX2:Hv:1, LoxA, More, omega-6 lipoxygenase, oxygenase, arachidonate 15-lip-, reticulocyte 15-lipoxygenase-1, reticulocyte 15-LOX, reticulocyte-type 15-human lipoxygenase, reticulocyte-type 15-lipoxygenase, reticulocyte-type 15-LO-1, reticulocyte-type of 15-LOX-1, SLO, soybean 15-lipoxygenase, soybean lipoxygenase-3

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.33 arachidonate 15-lipoxygenase

KM Value

KM Value on EC 1.13.11.33 - arachidonate 15-lipoxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0289 - 0.136
(16(R),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0227 - 0.0236
(16(S),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0368 - 0.293
(17(R),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0313 - 0.236
(17(S),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0083
1-linoleoyl lysophosphatidic acid
-
pH 7.4, 25°C
0.0175
1-linoleoyl lysophosphatidylcholine
-
pH 7.4, 25°C
0.0022 - 0.013
arachidonate
0.0025 - 1.1
arachidonic acid
0.09
dilinoleoyl phosphatidic acid
-
pH 7.4, 25°C
0.0717
dilinoleoyl phosphatidylcholine
-
pH 7.4, 25°C
0.003 - 0.0772
linoleic acid
0.01
lipoic acid
-
splice variant 15-LOb1
0.0052 - 4.2
O2
additional information
additional information
-