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1.13.11.33: arachidonate 15-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 15-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.33

Reaction

arachidonate
+
O2
=
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Synonyms

12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-LO, 12/15-LOX, 12/15LO, 15(S)-lipoxygenase-1, 15-hLO, 15-hLO-1, 15-hLO-2, 15-lipoxygenase, 15-lipoxygenase 1, 15-lipoxygenase 2, 15-lipoxygenase type 1, 15-lipoxygenase type 2, 15-lipoxygenase type-1, 15-lipoxygenase-1, 15-lipoxygenase-2, 15-lipoxygenase-I, 15-LO, 15-LO-1, 15-LO-2, 15-LO-I, 15-LOX, 15-LOX type 1, 15-LOX-1, 15-LOX-2, 15-LOX-A, 15-LOX2, 15-rLO, 15-rLO-1, 15-sLO, 15LO1, 15S-lipoxygenase, 15S-LOX1, ALOX12, Alox15, ALOX15-2, ALOX15B, arachidonate 12/15-lipoxygenase, arachidonate 15-lipoxygenase, arachidonate 15-lipoxygenase-1, arachidonic acid 15-lipoxygenase, arachidonic acid 15-lipoxygenase-1, cardiac 12/15-LOX, endothelial 15-lipoxygenase-1, epidermis-type 15-LOX, human prostate epithelial 15-lipoxygenase-2, linoleic acid omega-6-lipoxygenase, lipoxygenase L-1, lipoxygenase-1, LO-1, LOX-1, LOX2, LOX2:Hv:1, LoxA, More, omega-6 lipoxygenase, oxygenase, arachidonate 15-lip-, reticulocyte 15-lipoxygenase-1, reticulocyte 15-LOX, reticulocyte-type 15-human lipoxygenase, reticulocyte-type 15-lipoxygenase, reticulocyte-type 15-LO-1, reticulocyte-type of 15-LOX-1, SLO, soybean 15-lipoxygenase, soybean lipoxygenase-3

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.33 arachidonate 15-lipoxygenase

Expression

Expression on EC 1.13.11.33 - arachidonate 15-lipoxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
12/15-LO is upregulated in white adipose tissue in the obese state. The potent vasoconstricting and pro-inflammatory hormone angiotensin II (Ang II) led to increases in leukocyte-type 12-LO mRNA and protein levels, as well as increased enzyme activity
12/15-LOX activity is enhanced during chronic, but not acute, toxoplasmosis
12/15-LOX mRNA expression in cultured aortic smooth muscle cells is upregulated by angiotensin II, ATII. ATII also stimulates production of LOX-derived HETEs in arterial vessels and the kidney
15LO1 is highly expressed in fresh epithelial cells from severe asthmatic patients
-
a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts
allergen challenge up-regulates the expression of 12/15-LO in airway epithelial cells in mice. Interleukin-4 and interleukin-13 are inducers
-
demethylation of DNA in some cell lines increases 15-LOX-1 expression. Increased levels of 15-LOX-1 are associated with downregulation of GATA-6 in Caco-2 colon cancer cells treated with sodium butyrate to induce cell differentiation and apoptosis. Activation of the cGMP-PKG system can induce the cellular expression of 15-LOX-1 in SW-480 colon cancer cells. 5-aza-2-deoxycytidine increases 15-LOX-1 expression. Interleukin-4 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines. Interleukin-13 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines
-
expression of 12/15-LOX pathway is upregulated in the diabetic heart
hypoxia increases ALOX15 in human muscle cells
-
increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients. Patients with chronic obstructive pulmonary disease also display an increased expression of 15-LO-1 in bronchial biopsies. Interleukin-4 and interleukin-13 are inducers
-
induction by interleukin-4 and interleukin-13
-
interleukin-13 induces 15LO1 expression and production of intracellular 15-hydroxyeicosatetraenoic acid conjugated to phosphotidylethanolamine in vitro. 15-hydroxyeicosatetraenoic acid enhances interleukin-13 induced MUC5AC expression in vitro
-
interleukin-4 increases the expression of 15-LOX-1 and of downstream targets of p53
-
ischemia of the heart leads to increased expression of ALOX15
-
level of 15-LOX expression is dose-dependently induced by UVA and UVB-irradiation. Psoralen plus ultraviolet A, UVA-photochemotherapy significantly increases 15-LOX expression
-
normal human airway epithelial cells treated with interleukin-4 express higher levels of 15-LOX-1 than transfected A549 cells
-
the level of LoxA expression is increased when Pseudomonas aeruginosa undergoes the transition to a biofilm mode of growth