1.13.11.31: arachidonate 12-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.

Reaction

Synonyms

(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 15-LOX-1, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox12e, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LOX1, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, WP_046712474, zf12-LOX

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.31 arachidonate 12-lipoxygenase

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Results	in table
9	Activating Compound
24	AA Sequence
20	Application
1	CAS Registry Number
48	Cloned(Commentary)
3	Crystallization (Commentary)
4450	Disease/ Diagnostics
19	Expression
105	General Information
3	General Stability
96	IC50 Value
205	Inhibitors
24	kcat/KM [mM/s]
5	Ki Value [mM]
60	KM Value [mM]
26	Localization
22	Metals/Ions
9	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
603	Organism
10	Pathway
6	PDB ID
25	pH Optimum
4	pH Range
64	Protein Variants
29	Purification (Commentary)
1	Reaction
5	Reaction Type
173	Reference
209	Source Tissue
18	Specific Activity [micromol/min/mg]
12	Storage Stability
315	Substrates and Products (Substrate)
16	Subunits
249	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
34	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0007

(2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octa-dienyl-O-(alpha-L-rhamnopyranosyl)-(1''->3')-(4'''-O-cis-p-coumaroyl)-beta-D-glucopyranoside

Sus scrofa

P16469

pH 7.4, 30°C, recombinant leukocyte-type enzyme

743324

0.0017

(2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octadienyl-O-(alpha-L-rhamnopyranosyl)-(1''->3')-(4'''-O-trans-p-coumaroyl)-beta-D-glucopyranoside

Sus scrofa

P16469

pH 7.4, 30°C, recombinant leukocyte-type enzyme

743324

0.0007

2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol

Homo sapiens

-

IC50: 0.0007 mM

659680

0.0041

2,3,4,5-tetrabromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol

Homo sapiens

-

IC50: 0.0041 mM

659680

0.00041

2,3,5-tribromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol

Homo sapiens

-

IC50: 0.00041 mM

659680

0.012

2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol

Homo sapiens

-

IC50: 0.012 mM

659680

0.007

2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol

Homo sapiens

-

IC50: 0.007 mM

659680

0.00078

3'-chloro-7,8-dihydroxyisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.0075

3,15-dihydroxy-8,11,13-eicosatrienoic acid

Homo sapiens

-

IC50: 0.0075 mM

395415

0.05

3,4,6,8-tetrabromooxanthren-1-ol

Homo sapiens

-

IC50: 0.05 mM

659680

0.006

3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol

Homo sapiens

-

IC50: 0.006 mM

659680

0.047

3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol

Homo sapiens

-

IC50: 0.047 mM

659680

0.03

3,6,8-tribromooxanthren-1-ol

Homo sapiens

-

IC50: 0.03 mM

659680

0.0004

3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide

Homo sapiens

-

IC50: 0.0004 mM

659680

0.017

4',6,7-trihydroxyisoflavan

Homo sapiens

-

pH 7.5, 22°C

685526

0.0038

4',6,7-trihydroxyisoflavanone

Homo sapiens

-

pH 7.5, 22°C

685526

0.0087

4',6,7-trihydroxyisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.00048

4'-chloro-7,8-dihydroxyisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.0081

4,15-dihydroxy-5,8,11,13-eicosatetraenoic acid

Homo sapiens

-

IC50: 0.0081 mM

395415

0.01

4,4'-propane-2,2-diylbis(2,6-dibromophenol)

Homo sapiens

-

IC50: 0.01 mM

659680

0.000032

4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

0.0008

5,15-dihydroxy-5,8,11,13,17-eicosapentaenoic acid

Homo sapiens

-

IC50: 0.0008 mM

395415

0.00006

5,8,11,14-Eicosatetraynoic acid

Sus scrofa

-

IC50: 0.00006 mM

395428

0.0002

5-(methylamino)-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carbonitrile

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

-

0.00055

5-chloro-N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

-

0.0004

6,17-dihydroxy-4,7,10,13,15,19-eicosahexaenoic acid

Homo sapiens

-

IC50: 0.0004 mM

395415

0.000197

6,6a,11,11a-tetrahydro[1]benzothiopyrano[4,3-b]indole

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

-

0.011

6,7-dihydroxy-3',4'-methylenedioxyisoflavan

Homo sapiens

-

pH 7.5, 22°C

685526

0.1

6,7-dihydroxy-3',4'-methylenedioxyisoflavone

Homo sapiens

-

above, pH 7.5, 22°C

685526

0.015

6,7-dihydroxy-3'-methylisoflavan

Homo sapiens

-

pH 7.5, 22°C

685526

0.014

6,7-dihydroxy-3'-methylisoflavanone

Homo sapiens

-

pH 7.5, 22°C

685526

0.0076

6,7-dihydroxy-4'-methoxyisoflavan

Homo sapiens

-

pH 7.5, 22°C

685526

0.0016

6,7-dihydroxy-4'-methoxyisoflavanone

Homo sapiens

-

pH 7.5, 22°C

685526

0.1

6,7-dihydroxy-4'-methoxyisoflavone

Homo sapiens

-

above, pH 7.5, 22°C

685526

0.0058

6,7-dihydroxy-4'-nitroisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.1

7,8-dihydroxy-3',4'-dimethoxyisoflavan

Homo sapiens

-

above, pH 7.5, 22°C

685526

0.0036

7,8-dihydroxy-3'-methylisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.00062

7,8-dihydroxy-3'-trifluoromethylisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.026

7,8-dihydroxy-4'-methoxyisoflavan

Homo sapiens

-

pH 7.5, 22°C

685526

0.07

7,8-dihydroxy-4'-methylisoflavan

Homo sapiens

-

pH 7.5, 22°C

685526

0.0016

7,8-dihydroxy-4'-methylisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.0064

7,8-dihydroxyisoflavone

Homo sapiens

-

pH 7.5, 22°C

685526

0.00058

alpha-mangostin

Homo sapiens

P18054

pH 8.0, recombinant enzyme

685525

0.0023

bestatin 7

Homo sapiens

-

IC50: 0.0023 mM

659680

0.009

dysidenin

Homo sapiens

P18054

above, pH 8.0, recombinant enzyme

685525

0.00009

ethyl 6-chloro-3-[(3S)-3-hydroxy-7-methyloctanoyl]-2,3-dihydro-1H-indole-2-carboxylate

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

-

0.0049

michellamine B

Homo sapiens

P18054

pH 8.0, recombinant enzyme

685525

0.00043 - 0.1

ML355

2 entries

0.000099

N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

0.0001

N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

0.075

N-([5-chloro-2-(dimethylamino)-8-hydroxyquinolin-7-yl](furan-2-yl)methyl)acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.075

N-([5-chloro-8-hydroxy-2-(piperidin-1-yl)quinolin-7-yl](furan-2-yl)methyl)acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.075

N-[(2,5-dichloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.075

N-[(4-chloro-1-hydroxynaphthalen-2-yl)(furan-2-yl)methyl]acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.002

N-[(5-bromo-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.002

N-[(5-bromo-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.001

N-[(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.014

N-[(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.075

N-[(5-bromofuran-2-yl)(5-chloro-8-hydroxyquinolin-7-yl)methyl]propanamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.003

N-[(5-chloro-8-hydroxy-1,2,3,4,4a,8a-hexahydroquinolin-7-yl)(furan-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.05

N-[(5-chloro-8-hydroxyquinolin-7-yl)(4-fluorophenyl)methyl]propanamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.15

N-[(5-chloro-8-hydroxyquinolin-7-yl)(4-methylphenyl)methyl]propanamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.0035

N-[(5-chloro-8-hydroxyquinolin-7-yl)(5-methylthiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.003

N-[(5-chloro-8-hydroxyquinolin-7-yl)(cyclopropyl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.0016

N-[(5-chloro-8-hydroxyquinolin-7-yl)(cyclopropyl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.025

N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]-4-methylbenzamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.003

N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.025

N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]benzamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.001

N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.001

N-[(5-chloro-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.001

N-[(5-chloro-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.15

N-[(5-chloro-8-hydroxyquinolin-7-yl)methyl]acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.075

N-[(5-chloro-8-methoxyquinolin-7-yl)(furan-2-yl)methyl]propanamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.005

N-[(5-fluoro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.002

N-[(5-fluoro-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.0008

N-[(8-hydroxy-5-nitroquinolin-7-yl)(thiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.0034

N-[(8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.025

N-[(R)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.025

N-[(R)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.00043

N-[(S)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.00038

N-[(S)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.0026

N-[1-(5-chloro-8-hydroxyquinolin-7-yl)-2-methylpropyl]acetamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.0012

N-[1-(5-chloro-8-hydroxyquinolin-7-yl)-2-methylpropyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.15

N-[1-(5-chloro-8-hydroxyquinolin-7-yl)ethyl]acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.05

N-[1-(5-chloro-8-hydroxyquinolin-7-yl)ethyl]propanamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.075

N-[1-(5-fluoro-8-hydroxyquinolin-7-yl)ethyl]acetamide

Homo sapiens

-

value above, pH 8.0, 23°C

728093

0.0012

N-[furan-2-yl(8-hydroxy-5-nitroquinolin-7-yl)methyl]propanamide

Homo sapiens

-

pH 8.0, 23°C

728093

0.000025

NDGA

Homo sapiens

P16050

pH not specified in the publication, temperature not specified in the publication

765651

0.1

neodysidenin

Homo sapiens

P18054

above, pH 8.0, recombinant enzyme

685525

0.0022 - 0.0051

nordihydroguaiaretic acid

2 entries

0.00021

NSC172033

Homo sapiens

P18054

pH 8.0, recombinant enzyme

685525

0.00015

NSC292213

Homo sapiens

P18054

pH 8.0, recombinant enzyme

685525

0.00019

NSC617570

Homo sapiens

P18054

pH 8.0, recombinant enzyme

685525

0.00044

quercetin

Homo sapiens

-

pH and temperature not specified in the publication

712802

0.00043

ML355

Homo sapiens

P18054

wild-type, pH 8,23°C

764187

0.1

ML355

Homo sapiens

P18054

above 0.1 mM, mutant L183E/L187E, pH 8,23°C

764187

0.0022

nordihydroguaiaretic acid

Sus scrofa

-

IC50: 0.0022 mM

395428

0.0051

nordihydroguaiaretic acid

Homo sapiens

-

IC50: 0.0051 mM

659680