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1.13.11.24: quercetin 2,3-dioxygenase

This is an abbreviated version!
For detailed information about quercetin 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.24

Reaction

quercetin
+
O2
=
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate
 +
CO
 +
H+

Synonyms

2,3-QD, 2,3QD, 2,4-QD, Co-QDO, Co-QueD, Cu2+-containing 2,4-QD, cupin domain-containing protein, Fe-QDO, Fe-QueD, flavonol 2,4-dioxygenase, flavonol 2,4-oxygenase, manganese quercetin 2,3-dioxygenase, manganese quercetin dioxygenase, Mn-QDO, Mn-QueD, Ni-QueD, nickel quercetinase, pirin, QDO, QdoI, QueD, quercetin 2,4-dioxygenase, quercetin dioxygenase, quercetinase, type III extradiol dioxygenase, VdQase, YxaG

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.24 quercetin 2,3-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.24 - quercetin 2,3-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1Z,3Z)-N,N'-di(pyridin-2-yl)-1H-isoindole-1,3(2H)-diimine
-
-
1,10-phenanthroline
-
0.21 mM, 46% residual activity
1H-2-benzyl-3-hydroxy-4-oxoquinolin
competitive
2,2'-dipyridyl
-
0.18 mM, 57% residual activity
2-(4-{bis[1-methyl-2-(propan-2-yl)-1H-imidazol-4-yl]methyl}-1-methyl-1H-imidazol-2-yl)-2-methylpropanoic acid
-
-
2-mercaptoethanol
-
-
2-{4-[hydroxy(di-1H-imidazol-4-yl)methyl]-1H-imidazol-2-yl}-2-methylpropanoic acid
-
-
3-hydroxyflavone
-
competitive inhibition
8-hydroxyquinoline
alpha-alpha'-dipyridyl
-
at 1 mM or more
alpha-naphthoquinoline
-
-
chloro[(4-phenoxy-1,4,7-triazonan-1-yl-kappa3N1,N4,N7)acetato-kappaO]copper
-
-
Cu-EDTA
abolishes the quercetinase activity
-
diethyldithiocarbamate
Diphenylthiocarbazone
-
-
Dithiol
-
at microM concentrations or less
dithiothreitol
-
-
Dithizone
-
at microM concentrations or less
DTT
-
Mn QueD: 96% activity remains after 15 min incubation with 1 mM reagent
ethylxanthate
H2O2
-
Co QueD: 93% activity remains after 15 min incubation with 1 mM reagent, Mn QueD: 82% activity remains after 15 min incubation with 1 mM reagent
kojic acid
morin
-
competitive inhibition
NaCN
-
Co QueD: 91% activity remains after 15 min incubation with 1 mM reagent, Mn QueD: 89% activity remains after 15 min incubation with 1 mM reagent
O-ethylxanthate
-
6 mM, 51% residual activity
O-ethylxanthic acid
-
Co QueD: 69% activity remains after 15 min incubation with 1 mM reagent, Mn QueD: 100% activity remains after 15 min incubation with 1 mM reagent
o-phenanthroline
-
at 1 mM or more
prohexadione-Ca
abolishes the quercetinase activity
Quinoline
-
-
Sodium ascorbate
-
Mn QueD: 80% activity remains after 15 min incubation with 1 mM reagent
Sodium dithionite
-
-
Toluene-3,4-dithiol
-
-
[3-(hydroxy-kappaO)-2-phenyl-4H-chromen-4-onato-kappaO4][bis(triphenylphosphane)]copper
-
-
{N,N-bis[(1-methyl-1H-imidazol-4-yl-kappaN3)methyl]glycinato-kappa2N,O}(dichloro)ferrate(1-)
-
-