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1.13.11.24: quercetin 2,3-dioxygenase

This is an abbreviated version!
For detailed information about quercetin 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.24

Reaction

quercetin
+
O2
=
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate
+
CO
+
H+

Synonyms

2,3-QD, 2,3QD, 2,4-QD, Co-QDO, Co-QueD, Cu2+-containing 2,4-QD, cupin domain-containing protein, Fe-QDO, Fe-QueD, flavonol 2,4-dioxygenase, flavonol 2,4-oxygenase, manganese quercetin 2,3-dioxygenase, manganese quercetin dioxygenase, Mn-QDO, Mn-QueD, Ni-QueD, nickel quercetinase, pirin, QDO, QdoI, QueD, quercetin 2,4-dioxygenase, quercetin dioxygenase, quercetinase, type III extradiol dioxygenase, VdQase, YxaG

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.24 quercetin 2,3-dioxygenase

Disease

Disease on EC 1.13.11.24 - quercetin 2,3-dioxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
High levels of ?-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer.
Mutational Landscape of Pirin and Elucidation of the Impact of Most Detrimental Missense Variants That Accelerate the Breast Cancer Pathways: A Computational Modelling Study.
Carcinogenesis
Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis.
Carcinoma
Curcumin decreases epithelial?mesenchymal transition by a Pirin?dependent mechanism in cervical cancer cells.
Infections
Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin.
Lymphoma, B-Cell
Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.
Melanoma
A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches.
Neoplasm Metastasis
Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling.
Proteomics analysis of differentially expressed metastasis-associated proteins in adenoid cystic carcinoma cell lines of human salivary gland.
Neoplasms
Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element.
Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells.
Human Papillomavirus 16 E7 Promotes EGFR/PI3K/AKT1/NRF2 Signaling Pathway Contributing to PIR/NF-?B Activation in Oral Cancer Cells.
Pirin inhibits cellular senescence in melanocytic cells.
Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling.
Proteomics analysis of differentially expressed metastasis-associated proteins in adenoid cystic carcinoma cell lines of human salivary gland.
Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice.
Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis.
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
Pancreatic Neoplasms
Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis.
Prostatic Neoplasms
Pirin down-regulates the EAF2/U19 protein and alleviates its growth inhibition in prostate cancer cells.
Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p.
Pulmonary Disease, Chronic Obstructive
Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice.
Uterine Cervical Neoplasms
Curcumin decreases epithelial?mesenchymal transition by a Pirin?dependent mechanism in cervical cancer cells.