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1.13.11.19: cysteamine dioxygenase

This is an abbreviated version!
For detailed information about cysteamine dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.19

Reaction

2-aminoethanethiol
+
O2
=
Hypotaurine

Synonyms

2-aminoethanethiol dioxygenase, ADO, CDO, cysteamine oxygenase, Gm237, oxygenase, cysteamine, oxygenase, cysteamine di-, persulfurase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.19 cysteamine dioxygenase

General Information

General Information on EC 1.13.11.19 - cysteamine dioxygenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
ADO catalyzes conversion of N-terminal cysteine to cysteine sulfinic acid, reaction of EC 1.13.11.20, and is related to the plant cysteine oxidases that mediate responses to hypoxia by an identical post-translational modification. In human cells ADO regulates the RGS4/5 (regulator of G-protein signalling) N-degron substrates, modulates G-protein coupled Ca2+ signals and MAPK activity, and acts on N-terminal cysteine proteins including the angiogenic cytokine IL-32. Inactivation of ADO leads to constitutive upregulation of endogenous and transfected RGS4 and RGS5 proteins irrespective of oxygen levels