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1.13.11.18: persulfide dioxygenase

This is an abbreviated version!
For detailed information about persulfide dioxygenase, go to the full flat file.

Wordmap for 1.13.11.18

Word Map on EC 1.13.11.18 Wordmap for 1.13.11.18

Reaction

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S-sulfanylglutathione
+
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O2
+
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H2O
=
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glutathione
+
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sulfite
+ 2 H+

Synonyms

AFE_0269, BAE27_01805, BpPRF, cPDO-PT, CstB, ETHE1, ETHE1-like sulfur dioxygenase, Ethe2, Fe(II)-containing persulfide dioxygenase, Gly3, PDO, PRF, SDO, SOR, sulfide dioxygenase, sulfur dioxygenase, sulfur oxygenase, sulfur oxygenase/reductase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                EC 1.13.11.181.13.11.18 persulfide dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.18 - persulfide dioxygenase

for references in articles please use BRENDA:EC1.13.11.18

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
diethyldithiocarbamate
-
-
DTT
23% inhibition at 1 mM
gamma-glutamyl-homocysteinyl-glycine
mechanism-based inhibitor, accepted as an alternative substrate and converted to glutamyl-homocysteinyl-SO2H, which fails to undergo the final hydrolysis step in the catalytic cycle, leading to inhibition. Maximum inhibition to 30% of initial activity
H2O2
-
strong inhibition, reversible by subsequent addition of catalase and glutathione
sulfite
-
sulfite build up can potentially inhibit PDO activity
tris(2-carboxyethyl)phosphine
-
additional information
-
no effect by thiosulfate
-