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1.13.11.18: persulfide dioxygenase

This is an abbreviated version!
For detailed information about persulfide dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.18

Reaction

S-sulfanylglutathione
+
O2
+
H2O
=
glutathione
+
sulfite
+ 2 H+

Synonyms

AFE_0269, BAE27_01805, BpPRF, cPDO-PT, CstB, ETHE1, ETHE1-like sulfur dioxygenase, Ethe2, Fe(II)-containing persulfide dioxygenase, Gly3, PDO, PRF, SDO, SOR, sulfide dioxygenase, sulfur dioxygenase, sulfur oxygenase, sulfur oxygenase/reductase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.18 persulfide dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.18 - persulfide dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
diethyldithiocarbamate
-
-
DTT
23% inhibition at 1 mM
gamma-glutamyl-homocysteinyl-glycine
mechanism-based inhibitor, accepted as an alternative substrate and converted to glutamyl-homocysteinyl-SO2H, which fails to undergo the final hydrolysis step in the catalytic cycle, leading to inhibition. Maximum inhibition to 30% of initial activity
-
H2O2
-
strong inhibition, reversible by subsequent addition of catalase and glutathione
sulfite
-
sulfite build up can potentially inhibit PDO activity
tris(2-carboxyethyl)phosphine
-
additional information
-
no effect by thiosulfate
-