Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.13.11.12: linoleate 13S-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 13S-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.12

Reaction

alpha-linolenate
+
O2
=
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate

Synonyms

(13S)-lipoxygenase, 13-lipoxygenase, 13-LOX, 13S-lipoxygenase, 15-lipoxygenase-1, 15-LOX-1, 9/13-LOX, acidic lipoxygenase, Alox15, arachidonic acid 15S-lipoxygenating enzyme, AtLOX-2, AtLOX-3, AtLOX-4, AtLOX-6, CmLOX10, CmLOX13, iron 13S-lipoxygenase, liipoxygenase, linoleate 13-lipoxygenase, linoleate 13S-lipoxygenase, linoleate oxygen oxidoreductase, linoleate: oxygen oxidoreductase, linoleate:oxygen oxidoreductase, lipoxygenase, lipoxygenase 2, lipoxygenase-1, lipoxygenase-2, lipoxygenase-3, lipoxygenase-4, lipoxygenase-6, LO-1, LOX, LOX-1, LOX-2, LOX1, LOX10, LOX11, LOX12, LOX2, LOX2:Hv:1, LOX2:Md:2b, LOX2b, LOX3, LOX4, LOX6, LOX7, LOX8, LOX9, LoxA, Lpx-A2, MSD2, Oep1LOX2, Oep2LOX2, omega-6 linoleate lipoxygenase, PA-LOX, RCI-1, SBLO-1, secreted lipoxygenase, SLO, soybean lipoxygenase-1, StLOX2, StLOX3, type-1 LOX, type-2 13-LOX

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.12 linoleate 13S-lipoxygenase

Substrates Products

Substrates Products on EC 1.13.11.12 - linoleate 13S-lipoxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(15S)-hydroperoxyeicosatetraenoic acid + O2
(8S,15S)-dihydroperoxyeicosatetraenoic acid + (5S,15S)-dihydroperoxyeicosatetraenoic acid
show the reaction diagram
-
-
-
-
?
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-enoic acid + O2
?
show the reaction diagram
(6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid + O2
?
show the reaction diagram
-
-
-
-
?
(7Z,10Z,13Z)-hexadecatrienoic acid + O2
?
show the reaction diagram
-
lipoxygenase 2 produces 7- (21.5%), 8- (12.3%), 10- (12.9%), 11- (14.5%), 13- (14%), and 14- (19.6%) hydroperoxides of 16:3, as well as a significant amount of bis-allylic 9-hydroperoxide (5.2%)
-
-
?
(9Z,12Z)-octadeca-9,12-dienoic acid + O2
?
show the reaction diagram
(9Z,12Z,15Z)-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
show the reaction diagram
(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
show the reaction diagram
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2
5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5S,15S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
show the reaction diagram
-
-
-
?
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2
5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5S,15S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
show the reaction diagram
-
-
-
?
all-cis-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
show the reaction diagram
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
show the reaction diagram
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
show the reaction diagram
alpha-linolenate + O2
(9Z,11E,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
show the reaction diagram
-
isoenzyme Oep1LOX2 and Oep2LOX2 both produce primarily 13-hydroperoxides from linoleic acid and linolenic acid. Linolenic acid is the preferred substrate for both isoenzymes (Vmax/KM is about 10fold higher for linolenic acid)
-
-
?
alpha-linolenate + O2
13-hydroperoxyoctadeca-9,11,15-trienoate
show the reaction diagram
-
-
-
?
alpha-linolenic acid + O2
13-S-hydroperoxyoctadeca-9, 11,15-trienoic acid
show the reaction diagram
alpha-linolenic acid + O2
?
show the reaction diagram
aniline blue + O2
?
show the reaction diagram
arachidonate + O2
(5Z,8Z,11Z,13E)-(12S)-12-hydroperoxyicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
show the reaction diagram
-
-
-
?
arachidonate + O2
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
show the reaction diagram
-
-
-
?
arachidonate + O2
?
show the reaction diagram
arachidonic acid + O2
(5Z,8Z,11Z, 13E,15S)-15-hydroperoxy-5,8,11,13-eicosatetraenoic acid
show the reaction diagram
-
-
-
-
?
arachidonic acid + O2
15-(S)-hydroperoxy-5(Z),8(Z),11(Z),13(E)-eicosatetraenoic acid
show the reaction diagram
isoform LOX2 shows 50% activity compared to alpha-linolenic acid
-
-
?
arachidonic acid + O2
?
show the reaction diagram
docosahexaenoic acid + O2
?
show the reaction diagram
gamma-linolenate + O2
(6Z,9Z,11E,13S)-13-hydroperoxy-6,9,11-octadecatrienoate
show the reaction diagram
-
-
-
?
gamma-linolenate + O2
?
show the reaction diagram
-
-
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
show the reaction diagram
linoleate + O2
(9Z,11E)-13-hydroperoxy-9,11-octadecadienoate
show the reaction diagram
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
show the reaction diagram
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
show the reaction diagram
linoleate + O2
13-hydroperoxyoctadeca-9,11-dienoate
show the reaction diagram
linoleate + O2
9-hydroperoxy octadecadienoic acid + 13-hydroperoxy octadecadienoic acid
show the reaction diagram
linoleic acid + O2
(10E,12Z)-13-hydroperoxy-10,12-octadecadienoate
show the reaction diagram
preferred substrate
-
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
show the reaction diagram
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
show the reaction diagram
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
show the reaction diagram
linoleic acid + O2
13(S)-hydroperoxy-9,11-octadecadienoic acid
show the reaction diagram
-
-
-
-
?
linoleic acid + O2
13(S)-hydroxyoctadecadienoic acid
show the reaction diagram
-
-
-
-
?
linoleic acid + O2
13-hydroxy-12-oxo-9-octadecenoic acid + 9-hydroxy-10-oxo-12-octadecenoic acid + 12-oxo-10-phytoenoic acid + 10-oxo-phytoenoic acid
show the reaction diagram
-
-
combination of 9- and 13-lipoxygenases, ratio 10:2:1:3
-
?
linoleic acid + O2
?
show the reaction diagram
linolenate + O2
?
show the reaction diagram
the enzyme oxygenates linolenic acid more effectively than linoleic acid
the product is not determined
-
?
linolenic acid + O2
13(S)-hydroperoxylinolenic acid
show the reaction diagram
-
-
-
-
?
linolenic acid + O2
?
show the reaction diagram
linoleyltrimethylammonium ion + O2
13-hydroperoxy-(9Z,11E,13S)-octadecadienyltrimethylammonium ion
show the reaction diagram
-
-
primarily
-
?
N-linolenoylethanolamide + O2
?
show the reaction diagram
-
-
-
-
?
N-linoleoylethanolamide + O2
?
show the reaction diagram
-
-
-
-
?
additional information
?
-