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(15S)-hydroperoxyeicosatetraenoic acid + O2
(8S,15S)-dihydroperoxyeicosatetraenoic acid + (5S,15S)-dihydroperoxyeicosatetraenoic acid
-
-
-
-
?
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-enoic acid + O2
?
(6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid + O2
?
-
-
-
-
?
(7Z,10Z,13Z)-hexadecatrienoic acid + O2
?
-
lipoxygenase 2 produces 7- (21.5%), 8- (12.3%), 10- (12.9%), 11- (14.5%), 13- (14%), and 14- (19.6%) hydroperoxides of 16:3, as well as a significant amount of bis-allylic 9-hydroperoxide (5.2%)
-
-
?
(9Z,12Z)-octadeca-9,12-dienoic acid + O2
?
(9Z,12Z,15Z)-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2
5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5S,15S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
-
-
-
?
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + O2
5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5S,15S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
-
-
-
?
all-cis-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
alpha-linolenate + O2
(9Z,11E,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
isoenzyme Oep1LOX2 and Oep2LOX2 both produce primarily 13-hydroperoxides from linoleic acid and linolenic acid. Linolenic acid is the preferred substrate for both isoenzymes (Vmax/KM is about 10fold higher for linolenic acid)
-
-
?
alpha-linolenate + O2
13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
?
alpha-linolenic acid + O2
13-S-hydroperoxyoctadeca-9, 11,15-trienoic acid
alpha-linolenic acid + O2
?
arachidonate + O2
(5Z,8Z,11Z,13E)-(12S)-12-hydroperoxyicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
-
-
?
arachidonate + O2
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
-
-
?
arachidonic acid + O2
(5Z,8Z,11Z, 13E,15S)-15-hydroperoxy-5,8,11,13-eicosatetraenoic acid
-
-
-
-
?
arachidonic acid + O2
15-(S)-hydroperoxy-5(Z),8(Z),11(Z),13(E)-eicosatetraenoic acid
isoform LOX2 shows 50% activity compared to alpha-linolenic acid
-
-
?
docosahexaenoic acid + O2
?
gamma-linolenate + O2
(6Z,9Z,11E,13S)-13-hydroperoxy-6,9,11-octadecatrienoate
-
-
-
?
gamma-linolenate + O2
?
-
-
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
linoleate + O2
(9Z,11E)-13-hydroperoxy-9,11-octadecadienoate
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
linoleate + O2
13-hydroperoxyoctadeca-9,11-dienoate
linoleate + O2
9-hydroperoxy octadecadienoic acid + 13-hydroperoxy octadecadienoic acid
linoleic acid + O2
(10E,12Z)-13-hydroperoxy-10,12-octadecadienoate
preferred substrate
-
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
linoleic acid + O2
13(S)-hydroperoxy-9,11-octadecadienoic acid
-
-
-
-
?
linoleic acid + O2
13(S)-hydroxyoctadecadienoic acid
-
-
-
-
?
linoleic acid + O2
13-hydroxy-12-oxo-9-octadecenoic acid + 9-hydroxy-10-oxo-12-octadecenoic acid + 12-oxo-10-phytoenoic acid + 10-oxo-phytoenoic acid
-
-
combination of 9- and 13-lipoxygenases, ratio 10:2:1:3
-
?
linolenate + O2
?
the enzyme oxygenates linolenic acid more effectively than linoleic acid
the product is not determined
-
?
linolenic acid + O2
13(S)-hydroperoxylinolenic acid
-
-
-
-
?
linoleyltrimethylammonium ion + O2
13-hydroperoxy-(9Z,11E,13S)-octadecadienyltrimethylammonium ion
-
-
primarily
-
?
N-linolenoylethanolamide + O2
?
-
-
-
-
?
N-linoleoylethanolamide + O2
?
-
-
-
-
?
additional information
?
-
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-enoic acid + O2
?
-
-
-
-
?
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-enoic acid + O2
?
-
-
-
-
?
(9Z,12Z)-octadeca-9,12-dienoic acid + O2
?
-
-
-
-
?
(9Z,12Z)-octadeca-9,12-dienoic acid + O2
?
-
-
-
-
?
(9Z,12Z,15Z)-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
(9Z,12Z,15Z)-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
all-cis-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
all-cis-9,12,15-octadecatrienoic acid + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
alpha-linolenate is the preferred substrate
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate
-
Lox2 and Lox3 are more active against linolenate compared to linoleate
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
alpha-linolenate + O2
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
-
-
-
-
?
alpha-linolenic acid + O2
13-S-hydroperoxyoctadeca-9, 11,15-trienoic acid
-
-
-
?
alpha-linolenic acid + O2
13-S-hydroperoxyoctadeca-9, 11,15-trienoic acid
100% activity
-
-
?
alpha-linolenic acid + O2
?
-
minor substrate
-
-
?
alpha-linolenic acid + O2
?
-
-
-
-
?
aniline blue + O2
?
69.7% decolorization after 35 min incubation
-
-
?
aniline blue + O2
?
69.7% decolorization after 35 min incubation
-
-
?
arachidonate + O2
?
-
-
-
-
?
arachidonate + O2
?
-
-
-
-
?
arachidonic acid + O2
?
isoform LOX3 shows 5% activity compared to alpha-linolenic acid
-
-
?
arachidonic acid + O2
?
isoform LOX4 shows 4% activity compared to alpha-linolenic acid
-
-
?
arachidonic acid + O2
?
isoform LOX6 shows 8% activity compared to alpha-linolenic acid
-
-
?
arachidonic acid + O2
?
-
-
-
?
arachidonic acid + O2
?
-
-
-
?
arachidonic acid + O2
?
very low activity and specific activity towards arachidonic acid
-
-
?
docosahexaenoic acid + O2
?
isoform LOX2 shows 56% activity compared to alpha-linolenic acid
-
-
?
docosahexaenoic acid + O2
?
isoform LOX3 shows 7% activity compared to alpha-linolenic acid
-
-
?
docosahexaenoic acid + O2
?
isoform LOX4 shows 8% activity compared to alpha-linolenic acid
-
-
?
docosahexaenoic acid + O2
?
isoform LOX6 shows 31% activity compared to alpha-linolenic acid
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
lipoxygenase 2 specifically oxidizes linoleate into 13-hydroperoxide
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
primary product
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
linoleate + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
linoleate + O2
(9Z,11E)-13-hydroperoxy-9,11-octadecadienoate
-
isoenzyme Oep1LOX2 and Oep2LOX2 both produce primarily 13-hydroperoxides from linoleic acid and linolenic acid. Linolenic acid is the preferred substrate for both isoenzymes (Vmax/KM is about 10fold higher for linolenic acid)
-
-
?
linoleate + O2
(9Z,11E)-13-hydroperoxy-9,11-octadecadienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
the enzyme oxygenates linolenic acid more effectively than linoleic acid
the enzyme forms exclusively (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
the ratio of (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate to (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate is 87:13 for the enzyme from cucumber cotyledons, and 84:16 for the recombinant enzyme. A linoleate 9-LOX preferentially oxygenates free fatty acids whereas a linoleate 13-LOX is capable of oxygenating triolein to significantly higher degrees in all positions of the triacylglycerol. For 9-LOXs, the carboxylate anion of the substrate may be the binding or recognition site within the catalytic pocket of the enzyme, whereas in the case of 13-LOXs the unpolar hydrophobic tail of the fatty acid may be orientated towards the catalytic pocket of the enzyme. This may explain why unpolar substrates, such as trilinolein, are preferred substrates for linoleate 13-LOXs
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
ratio of (9Z,11E,13S)-13-hydroperoxy-11,13-octadecadienoate to (9Z,11E,13R)-13-hydroperoxy-11,13-octadecadienoate is 93:7
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
trilinolein and extracted polar and nonpolar lipids are oxidized with a ratio (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate to (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate of 6:94, 2:98, and 7:93. The stereoisomer ratios (S:R) of (9Z,11E)-13-hydroperoxy-9,11-octadecadienoate with these substrates are 82:18, 92:8, and 91:9 whereas (10E,12Z)-9-hydroperoxy-10,12-octadecadienoate is analyzed (R)-configured with 41:59, 47:53, and 40:60 (S:R)
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
the ratio of (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate to (9Z,11E,13R)-13-hydroperoxy-9,11-octadecadienoate is higher than 80:20 at all pH values tested
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
the ratio of the 13-hydroperoxy to 9-hydroperoxy fatty acid reaction is 98:2. The R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
Lox2 and Lox3 are more active against linolenate compared to linoleate
the R/S stereoconfiguration of the product is not determined
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
product identification by HPLC of recombinant extracellular enzyme, overview
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
product identification by HPLC of recombinant extracellular enzyme, overview
-
?
linoleate + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
-
?
linoleate + O2
13-hydroperoxyoctadeca-9,11-dienoate
-
-
-
?
linoleate + O2
13-hydroperoxyoctadeca-9,11-dienoate
the isozyme is specific for formation of the 13-H(p)ODE isomer (94%),very low 9-H(p)ODE activity (6%)
-
-
?
linoleate + O2
9-hydroperoxy octadecadienoic acid + 13-hydroperoxy octadecadienoic acid
-
-
9-hydroperoxy octadecadienoic acid is the product of EC 1.13.11.58
-
?
linoleate + O2
9-hydroperoxy octadecadienoic acid + 13-hydroperoxy octadecadienoic acid
-
-
9-hydroperoxy octadecadienoic acid is the product of EC 1.13.11.58
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
-
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
-
-
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
4-nitroso-N,N-dimethylaniline bleaching in the course of linoleate hydroperoxidation by soybean LOX-1
-
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
at pH-values higher than 7.5 the enzyme constitutes a linoleate 13-LOX whereas at lower pH, 9-H(P)ODE is the major reaction product. Glutamine 599 plays a role in pH-dependence of the reaction specificity
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
-
-
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
the recombinant enzyme shows a dual positional specificity, as it forms both 9- and 13-hydroperoxy octadecadienoic acid in a ratio 2:1
-
?
linoleic acid + O2
(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
-
preferred substrate
-
-
?
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
-
?
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
-
-
?
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate
-
-
-
-
?
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
best substrate
-
-
?
linoleic acid + O2
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
best substrate
-
-
?
linoleic acid + O2
?
isoform LOX2 shows 79% activity compared to alpha-linolenic acid
-
-
?
linoleic acid + O2
?
isoform LOX3 shows 12% activity compared to alpha-linolenic acid
-
-
?
linoleic acid + O2
?
isoform LOX4 shows 11% activity compared to alpha-linolenic acid
-
-
?
linoleic acid + O2
?
isoform LOX6 shows 17% activity compared to alpha-linolenic acid
-
-
?
linoleic acid + O2
?
-
-
-
-
?
linolenic acid + O2
?
LOX-2 displays a selective oxygenation of linolenic acid
-
-
?
linolenic acid + O2
?
LOX-3 displays a selective oxygenation of linolenic acid
-
-
?
linolenic acid + O2
?
LOX-4 displays a selective oxygenation of linolenic acid
-
-
?
linolenic acid + O2
?
LOX-6 displays a selective oxygenation of linolenic acid
-
-
?
linolenic acid + O2
?
-
-
-
?
linolenic acid + O2
?
-
-
-
-
?
linolenic acid + O2
?
-
-
-
?
linolenic acid + O2
?
good preference for linolenic acid
-
-
?
additional information
?
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
-
arachidonic acid is a poor substrate
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
the optimal substrate concentration in the enzyme assay is 20 g/l
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
the optimal substrate concentration in the enzyme assay is 20 g/l
-
-
?
additional information
?
-
-
oxygenation of triolein by lipid body LOX leads to a trihydroperoxy derivative
-
-
?
additional information
?
-
-
product specificity of FoxLOX, by SP-HPLC/DAD analysis, overview
-
-
?
additional information
?
-
-
product specificity of FoxLOX, by SP-HPLC/DAD analysis, overview
-
-
?
additional information
?
-
-
no activity with oleic acid
-
-
-
additional information
?
-
-
LOX-1 barely reacts with (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate alone
-
-
?
additional information
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under anaerobic conditions, LOX-1 shows LTA synthase activity with (15S)-hydroperoxyeicosatetraenoic acid as substrate giving either 14,15-leukotriene A4 or 5,15-dihydroxyeicosatetraenoic acid
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identification of products, by biotransformation and mass spectrometry, determination of the stereochemistry of the major product, overview
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the enzyme also converts arachidonate into (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate, S/R ratio is 92:8
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the enzyme also converts arachidonate into (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate, S/R ratio is 92:8
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regio- and stereospecificity analysis of isozyme substrate specificity, recombinant LOX1:Md:1a, LOX1:Md:1c, LOX2:Md:2a and LOX2:Md:2b isozymes show 13/9-LOX, 9-LOX, 13/9-LOX and 13-LOX activity with linoleic acid, respectively. While products of LOX1:Md:1c and LOX2:Md:2b are S-configured, LOX1:Md:1a and LOX2:Md:2a form 13(R)-hydroperoxides as major products. Oxygenation in the carbon backbone of linoleic acid occurs either at carbon atom 9 (9-LOX) or 13 (13-LOX), forming the corresponding hydroperoxy derivatives, respectively. LOX enzymes are not perfectly specific and biocatalysts that produce more than 10% of the alternative regio-isomer are called dual positional specific LOX
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regio- and stereospecificity analysis of isozyme substrate specificity, recombinant LOX1:Md:1a, LOX1:Md:1c, LOX2:Md:2a and LOX2:Md:2b isozymes show 13/9-LOX, 9-LOX, 13/9-LOX and 13-LOX activity with linoleic acid, respectively. While products of LOX1:Md:1c and LOX2:Md:2b are S-configured, LOX1:Md:1a and LOX2:Md:2a form 13(R)-hydroperoxides as major products. Oxygenation in the carbon backbone of linoleic acid occurs either at carbon atom 9 (9-LOX) or 13 (13-LOX), forming the corresponding hydroperoxy derivatives, respectively. LOX enzymes are not perfectly specific and biocatalysts that produce more than 10% of the alternative regio-isomer are called dual positional specific LOX
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the enzyme also converts arachidonate to its (15S)-hydroperoxide. The enzyme shows no substrate preference
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the enzyme also converts arachidonate to its (15S)-hydroperoxide. The enzyme shows no substrate preference
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the enzyme also converts linolenate into the 13-hydroperoxyy fatty acid
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the enzyme also converts linolenate into the 13-hydroperoxyy fatty acid
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mitochondrial membrane oxygenase activity of the enzyme PA-LOX, overview. PA-LOX is capable of oxygenating both, arachidonic acid and linoleic acid, the two major polyenoic fatty acids found in animal biomembranes. The enzyme binds phospholipids at its active site
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LOXs catalyze the regio- and stereospecific dioxygenation of polyunsaturated fatty acids with a (1Z,4Z)-pentadiene structure
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