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1.13.11.12: linoleate 13S-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 13S-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.12

Reaction

alpha-linolenate
+
O2
=
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate

Synonyms

(13S)-lipoxygenase, 13-lipoxygenase, 13-LOX, 13S-lipoxygenase, 15-lipoxygenase-1, 15-LOX-1, 9/13-LOX, acidic lipoxygenase, Alox15, arachidonic acid 15S-lipoxygenating enzyme, AtLOX-2, AtLOX-3, AtLOX-4, AtLOX-6, CmLOX10, CmLOX13, iron 13S-lipoxygenase, liipoxygenase, linoleate 13-lipoxygenase, linoleate 13S-lipoxygenase, linoleate oxygen oxidoreductase, linoleate: oxygen oxidoreductase, linoleate:oxygen oxidoreductase, lipoxygenase, lipoxygenase 2, lipoxygenase-1, lipoxygenase-2, lipoxygenase-3, lipoxygenase-4, lipoxygenase-6, LO-1, LOX, LOX-1, LOX-2, LOX1, LOX10, LOX11, LOX12, LOX2, LOX2:Hv:1, LOX2:Md:2b, LOX2b, LOX3, LOX4, LOX6, LOX7, LOX8, LOX9, LoxA, Lpx-A2, MSD2, Oep1LOX2, Oep2LOX2, omega-6 linoleate lipoxygenase, PA-LOX, RCI-1, SBLO-1, secreted lipoxygenase, SLO, soybean lipoxygenase-1, StLOX2, StLOX3, type-1 LOX, type-2 13-LOX

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.12 linoleate 13S-lipoxygenase

Expression

Expression on EC 1.13.11.12 - linoleate 13S-lipoxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.04 mM honokiol markedly activates cellular 15-LOX-1 expression
-
cadmium induces lipoxygenase activity
-
expression of the tomato gene encoding 13-lipoxygenase, TomloxD, is stimulated by wounding, pathogen infection, jasmonate, and systemin
-
in all antisense transgenic rice lines and more than half of the sense lines the expression levels of LOX1, the levels of enzyme activity, and the levels of the endogenous LOX1 products (jasmonic acid, (Z)-3-hexenal and colneleic acid) at 6, 48, and 48 h after brown planthopper feeding respectively, are below the levels found in non-transgenic control plants
isoform LOX4 is not influenced by salt stress
-
isoforms LOX3 and 10 are immediately downregulated by heat stress. Isoforms LOX10 and 11 are immediately downregulated by cold stress. Isoform LOX12 is immediately downregulated by salt stress. Isoforms LOX4 and 10 are immediately downregulated by drought stress
-
isoforms LOX4, 11, and 12 are immediately upregulated by heat stress. Isoforms LOX4 and 12 are immediately upregulated by cold stress. Isoforms LOX3, 10, and 11 are immediately upregulated by salt stress. Isoforms LOX3 and 11 are immediately upregulated by drought stress
-
low temperature (4°C) significantly decreases the expression levels of isoforms LOX4, 10, and 11. High temperature (40°C) significantly decreases the expression level of isoform LOX3. NaCl treatment significantly decreases the expression levels of isoforms LOX3, 4, and 6
-
Lox is a low-expression gene, no expression in wild-type strain NRRL 3357
Lox is expressed in the complemented strains TSHB3.1C and TSHB3.5C. While complemented strain TSHB3.1C (harboring a single-copy insertion) expresses a clear transcript, complemented strain TSHB3.5C (harboring at least two copies of lox and likely more) produces a greatly increased transcript and also produces an additional smaller band, which is absent in the single-copy strain TSHB3.1C
LOX1 transcripts accumulate rapidly and transiently in response to wounding or brown planthopper attack, reaching a peak 3 h after wounding and 6 h after insect feeding. Transgenic rice lines show altered LOX1 activity
methyljasmonate-induced oxidative burst, causing considerable oxidative stress, leads to the induction of a fatty acid oxidation cascade, resulting in the synthesis of hydroxy-oxylipins and the upregulation of the 13-lipoxygenase pathway
-
Oep2LOX2 transcript levels increase in Picual and Arbequina mesocarps during development and ripening, showing a maximum at turning stage, whereas Oep1LOX2 exhibits constant expression levels in both olive varieties and tissues
-
the exposure to NaCl increases the isoforms LOX7 and LOX8 expression levels by 2.2fold and 3.7fold, respectively. The expression levels of isoforms LOX7, 8, and 9 are considerably upregulated by high (40°C) and low (4°C) temperatures and PEG treatment. Isoform LOX11 expression is upregulated approximately 5fold in response to the high-temperature (40°C) and PEG treatments
-
the expression levels of all isoforms are not affected by the Plasmodiophora brassicae infection
-
the LOX2 gene is upregulated after wounding plus water and wounding plus Manduca sexta oral secretions treatment
the LOX3 gene is upregulated after wounding plus water and wounding plus Manduca sexta oral secretions treatment
the up-regulation of the enzyme gene is a component of the durum wheat response to hyperosmotic stress. Under mannitol and NaCl stress, a strong increase in the enzyme activity is observed